ReviewJournal of the American Academy of Child and Adolescent Psychiatry2010
Genetically informative research on adolescent substance use: methods, findings, and challenges.
Review in Journal of the American Academy of Child and Adolescent Psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Adolescent music engagement is associated with less alcohol consumption and substance experimentation 5-11 years later: A genetically informative study.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Youth Correlates of Genetic Liability to Substance Use Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Comparing the Role of Selection in Early Adolescent Substance Use Disparities Related to Single-Mother Family Structures Across Three Affluent Countries.Demography · 2025Article
- Factors predicting the intention of drug abuse avoidance among adolescents in Pinlaung Township, Myanmar: predictive correlational design.BMC public health · 2024Article
- Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study.Development and psychopathology · 2022Article
- Substance use and common contributors to morbidity: A genetics perspective.EBioMedicine · 2022Review
- Extending the "Worst of Both Worlds" hypothesis to the developmental antecedents of crime and substance use: school bullying and alcohol experimentation.European child & adolescent psychiatry · 2022Article
- Promoter Specific Methylation ofFrontiers in genetics · 2022Article
- Shared Environmental Influences on Electronic Cigarette Use Among Adolescent and Young Adult Females.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.Journal of youth and adolescence · 2020Article
- Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents.International journal of environmental research and public health · 2019Article
- Depressive symptoms, sexual activity, and substance use among adolescents in Kampala, Uganda.African health sciences · 2019Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
- Assessing Associations in Substance Use across Three Generations: From Grandparents to Sons and from Sons to Their Children.Contemporary social science · 2018Article
- Relation between age at first alcohol drink & adult life drinking patterns in alcohol-dependent patients.The Indian journal of medical research · 2017Article
- The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use.Drug and alcohol dependence · 2017Article
- Examining the role of psychological distress in linking childhood maltreatment and alcohol use in young adulthood.The American journal on addictions · 2015Article
- Contextual risks linking parents' adolescent marijuana use to offspring onset.Drug and alcohol dependence · 2015Article
- Genetic and Environmental Interplay in Adolescent Substance Use Disorders.Current addiction reports · 2015Article
- An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction.Alcoholism, clinical and experimental research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo provide an overview of the genetic epidemiology of substance use and misuse in adolescents.
methodA selective review of genetically informative research strategies, their limitations, and key findings examining issues related to the heritability of substance use and substance use disorders in children and adolescents is presented.
resultsAdoption, twin, and extended-family designs have established there is a strong heritable component to liability to nicotine, alcohol, and illicit drug dependence in adults. However, shared environmental influences are relatively stronger in youth samples and at earlier stages of substance involvement (e.g., use). There is considerable overlap in the genetic influences associated with the abuse/dependence across drug classes, and shared genetic influences contribute to the commonly observed associations between substance-use disorders and externalizing and, to a lesser extent, internalizing psychopathology. Rapid technologic advances have made the identification of specific gene variants that influence risks for substance-use disorders feasible, and linkage and association (including genomewide association studies) have identified promising candidate genes implicated in the development of substance-use disorders.
conclusionsStudies using genetically informative research designs, including those that examine aggregate genetic factors and those examining specific gene variants, individually and in interaction with environmental influences, offer promising avenues not only for delineating genetic effects on substance-use disorders but also for understanding the unfolding of risk across development and the interaction between environmental and genetic factors in the etiology of these disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.