ArticleNeuroscience2011
Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights From (Female) Mice and (Wo)men.Biological psychiatry · 2025Article
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- TgF344-AD Rat Model of Alzheimer's Disease: Spatial Disorientation and Asymmetry in Hemispheric Neurodegeneration.Journal of Alzheimer's disease reports · 2023Article
- Vestibular/ocular motor symptoms in concussed adolescents are linked to retrosplenial activation.Brain communications · 2022Article
- The protective effect of early dietary fat consumption on Alzheimer's disease-related pathology and cognitive function in mice.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Functional differences in spatial processing along an anterior-posterior axis: are there implications for the retrosplenial cortex?Journal of neurophysiology · 2019Article
- Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit.Brain : a journal of neurology · 2016Review
- Moderate Peep After Tracheal Lipopolysaccharide Instillation Prevents Inflammation and Modifies the Pattern of Brain Neuronal Activation.Shock (Augusta, Ga.) · 2015Article
- Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice.Molecular neurodegeneration · 2015Article
- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.Progress in neurobiology · 2012Review
- Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue.Progress in neurobiology · 2012Review
- Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A mouse model of amyloid pathology was used to first examine using a cross sectional design changes in retrosplenial cortex activity in transgenic mice aged 5, 11, 17, and 23 months. Attention focused on: (1) overt amyloid labeled with β-amyloid((1-42)) and Congo Red staining, (2) metabolic function assessed by the enzyme, cytochrome oxidase, and (3) neuronal activity as assessed indirectly by the immediate-early gene (IEG), c-Fos. Changes in cytochrome oxidase and c-Fos activity were observed in the retrosplenial cortex in Tg2576 mice as early as 5 months of age, long before evidence of plaque formation. Subsequent analyses concentrating on this early dysfunction revealed at 5 months pervasive, amyloid precursor protein (APP)-derived peptide accumulation in the retrosplenial cortex and selective afferents (anterior thalamus, hippocampus), which was associated with the observed c-Fos hyporeactivity. These findings indicate that retrosplenial cortex dysfunction occurs during early stages of amyloid production in Tg2576 mice and may contribute to cognitive dysfunction.
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Registered trials
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