ArticleAntiviral research2011
Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model.
Article in Antiviral research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons.Journal of neuroinflammation · 2024Article
- SARS-CoV-2 Antiviral Therapy.Clinical microbiology reviews · 2021Review
- Potential Prophylactic Treatments for COVID-19.Viruses · 2021Review
- Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19.Current microbiology · 2021Review
- Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics.Frontiers in immunology · 2021Review
- The Immune Responses against Coronavirus Infections: Friend or Foe?International archives of allergy and immunology · 2021Review
- Adenovirus vectored IFN-α protects mice from lethal challenge of Chikungunya virus infection.PLoS neglected tropical diseases · 2020Article
- Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19.Frontiers in immunology · 2020Review
- Structure-Based Modeling of SARS-CoV-2 Peptide/HLA-A02 Antigens.Frontiers in medical technology · 2020Article
- Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status.Frontiers in immunology · 2020Review
- Review
- Interaction of the innate immune system with positive-strand RNA virus replication organelles.Cytokine & growth factor reviews · 2017Article
- Prophylactic and therapeutic intranasal administration with an immunomodulator, HiltonolAntiviral research · 2017Article
- Single dose of an adenovirus vectored mouse interferon-α protects mice from lethal EV71 challenge.Antiviral research · 2016Article
- Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice.Cell host & microbe · 2016Article
- A Recombinant Adenovirus Expressing Ovine Interferon Tau Prevents Influenza Virus-Induced Lethality in Mice.Journal of virology · 2016Article
- Coronavirus virulence genes with main focus on SARS-CoV envelope gene.Virus research · 2014Review
- Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes.Molecular therapy. Methods & clinical development · 2014Article
- Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs.Journal of virology · 2013Article
- Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (p<0.001), and body weights of these treated mice were unaffected by the challenge. In addition, low doses of mDEF201 protected lungs in a dose dependent manner as measured by a reduction in gross pathology. Intranasal treatment with mDEF201 ranging from 10(6) to 10(8)PFU significantly protected mice against a lethal SARS-CoV infection in a dose dependent manner up to 12h post infection (p<0.001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.