Evidence map›Paper›PMID 21093474›Full record

ReviewAdvances in enzyme regulation2011

Temporal and functional analysis of DNA replicated in early S phase.

David G Kaufman, Stephanie M Cohen, Paul D Chastain

Abstract readReview
In one paragraph

Review in Advances in enzyme regulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David G KaufmanDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. uncdgk@med.unc.edu
Stephanie M Cohen
Paul D Chastain
University of North Carolina at Chapel Hill · USUniversity of North Carolina Health Care · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
ENVIRONMENTAL PATHOLOGYT32ES007017 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAUFMAN, DAVID G. · 1985 to 2011
$5.1M
CANCER SUSCEPTIBILITY AND S PHASE INITIATION SITESR01CA084493 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAUFMAN, DAVID G. · 2000 to 2009
$2.5M
Identification of Areas of Oxidative Damage in Human Genomic DNAR21CA125337 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAUFMAN, DAVID G. · 2007 to 2008
$329k
NCI NIH HHS CA084493NCI NIH HHS CA125337NCI NIH HHS R01 CA084493NCI NIH HHS R21 CA125337NIEHS NIH HHS ES007017NIEHS NIH HHS P30 ES010126NIEHS NIH HHS T32 ES007017
6 · The paper itself

Abstract

In summary, recently developed technologies have begun to draw back the curtain of mystery that obscures some of the basic mechanisms of DNA replication at multiple levels. Studies using extended DNA and chromatin fiber techniques have proven valuable for identifying the location of origins of replication at specific genomic sites and determining their temporal order of replication, for identifying and quantifying sites of DNA damage and localizing chromatin proteins in relation to sites of DNA replication. The future potential of these methods include further discoveries in functional genomics and contributions to the elucidation of the histone code. Such studies could prove very valuable in studies of the mechanisms of cancer development, aging, and other processes of disordered genomic functioning.

Indexed as

DNA ReplicationS PhaseChromatinDNAHumansNeoplasmsChromatinDNA

Identifiers

PMID21093474
PMCPMC3079056
OpenAlexW2064696551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.