ArticleJournal of theoretical biology2011
Consequences of host heterogeneity, epitope immunodominance, and immune breadth for strain competition.
Article in Journal of theoretical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Beyond oncogenesis: the unexplored benefits of viruses in cancer immunity.Nature reviews. Cancer · 2026Review
- Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve.Journal of the Royal Society, Interface · 2025Article
- Measures of Population Immunity Can Predict the Dominant Clade of Influenza A (H3N2) in the 2017-2018 Season and Reveal Age-Associated Differences in Susceptibility and Antibody-Binding Specificity.Influenza and other respiratory viruses · 2024Article
- Measures of population immunity can predict the dominant clade of influenza A (H3N2) in the 2017-2018 season and reveal age-associated differences in susceptibility and antibody-binding specificity.medRxiv : the preprint server for health sciences · 2024Article
- Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.Cell host & microbe · 2024Article
- A speed limit on serial strain replacement from original antigenic sin.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A speed limit on serial strain replacement from original antigenic sin.bioRxiv : the preprint server for biology · 2024Article
- Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.bioRxiv : the preprint server for biology · 2023Article
- Antigenic escape is accelerated by the presence of immunocompromised hosts.Proceedings. Biological sciences · 2022Article
- Ecological and evolutionary dynamics of multi-strain RNA viruses.Nature ecology & evolution · 2022Review
- Influenza immune escape under heterogeneous host immune histories.Trends in microbiology · 2021Review
- Immune history and influenza virus susceptibility.Current opinion in virology · 2017Review
- Capturing the dynamics of pathogens with many strains.Journal of mathematical biology · 2016Review
- Analysis of symmetries in models of multi-strain infections.Journal of mathematical biology · 2014Article
- Pathogen evolution and the immunological niche.Annals of the New York Academy of Sciences · 2014Article
- Cocirculation of infectious diseases on networks.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
- Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.Cell host & microbe · 2013Article
- Synergistic capture of Clostridium botulinum type A neurotoxin by scFv antibodies to novel epitopes.Biotechnology and bioengineering · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Consumer-resource dynamics of hosts with their pathogens are modulated by complex interactions between various branches of hosts' immune systems and the imperfectly perceived pathogen. Multistrain SIR models tend to sweep competitive interaction terms between different pathogen strains into a single parameter representing cross-immunity. After reviewing several hypotheses about the generation of immune responses, we look into the consequences of assuming that hosts with identical immune repertoires respond to new pathogens identically. In particular, we vary the breadth of the typical immune response, or the average number of pathogen epitopes a host perceives, and the probability of perceiving a particular epitope. The latter quantity in our model is equivalent both to the degree of diversity in host responses at the population level and the relative immunodominance of different epitopes. We find that a sharp transition to strain coexistence occurs as host responses become narrow or skewed toward one epitope. Increasing the breadth of the immune response and the immunogenicity of different epitopes typically increases the range of cross-immunity values in which chaotic strain dynamics and competitive exclusion occur. Models attempting to predict the outcomes of strain competition should thus consider the potential diversity and specificity of hosts' responses to infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.