Evidence map›Paper›PMID 21093110›Full record

ArticleNeurobiology of aging2011

No association of psychosis in Alzheimer disease with neurodegenerative pathway genes.

Mary Ann A DeMichele-Sweet, Lambertus Klei, Bernie Devlin, Robert E Ferrell, Elise A Weamer, James E Emanuel, Oscar L Lopez, Robert A Sweet

Abstract read
In one paragraph

Article in Neurobiology of aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Differential Association of theInternational journal of molecular sciences · 2025
    Article
  5. A brain DNA co-methylation network analysis of psychosis in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Genetics of psychosis of Alzheimer disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Review
  9. Article
  10. Article
  11. Article
  12. Genetics of Psychosis in Alzheimer Disease.Current genetic medicine reports · 2014
    Article
  13. Article
  14. Review
  15. Cerebral correlates of psychotic syndromes in neurodegenerative diseases.Journal of cellular and molecular medicine · 2012
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mary Ann A DeMichele-SweetDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Lambertus Klei
Bernie Devlin
Robert E Ferrell
Elise A Weamer
James E Emanuel
Oscar L Lopez
Robert A Sweet

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
Prediction of Psychosis in Alzheimer DiseaseR01AG027224 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 2007 to 2021
$10.8M
NIA NIH HHS AG027224NIA NIH HHS AG05133NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG027224
6 · The paper itself

Abstract

Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amyloid beta (Aβ) protein and/or hyperphosphorylated microtubule-associated protein tau (MAPT): amyloid precursor protein (APP), beta-site amyloid precursor protein cleaving enzyme (BACE1), sortilin-related receptor (SORL1), and MAPT. Each gene was thoroughly interrogated with tag single-nucleotide polymorphisms (SNPs), and gene-based tests were used to enhance power. We found no association of these genes with AD + P.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesFemaleGenome-Wide Association StudyHumansLDL-Receptor Related ProteinsMaleMembrane Transport ProteinsNerve DegenerationPolymorphism, Single NucleotidePsychotic DisordersAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanLDL-Receptor Related ProteinsMAPT protein, humanMembrane Transport ProteinsSORL1 protein, humantau Proteins

Identifiers

PMID21093110
PMCPMC3065549

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.