ArticleJournal of the International Neuropsychological Society : JINS2011
Neuropathological associates of multiple cognitive functions in two community-based cohorts of older adults.
Article in Journal of the International Neuropsychological Society : JINS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Defining exceptional cognition in older adults: A systematic review of cognitive super-ageing.International journal of geriatric psychiatry · 2023Pooled it
- ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.Acta neuropathologica · 2014Pooled it
- Contribution of health history and neuropathologic changes to the likelihood of dementia in those with intermediate/high Alzheimer's pathology: findings from The 90 + Study.Acta neuropathologica · 2026Article
- Metabolic Regulatory Networks in Ferroptosis During Alzheimer's Disease, Mechanisms of Glial Cell Action, and Pathological Correlations with Neuritic Plaques.International journal of general medicine · 2026Review
- Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline.Acta neuropathologica · 2023Article
- Measuring Cognitive Health in Ethnically Diverse Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Comparison of Education and Episodic Memory as Modifiers of Brain Atrophy Effects on Cognitive Decline: Implications for Measuring Cognitive Reserve.Journal of the International Neuropsychological Society : JINS · 2021Article
- Leveraging Neuroimaging Tools to Assess Precision and Accuracy in an Alzheimer's Disease Neuropathologic Sampling Protocol.Frontiers in neuroscience · 2021Article
- Braak Stage, Cerebral Amyloid Angiopathy, and Cognitive Decline in Early Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Article
- Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort.Acta neuropathologica communications · 2019Article
- Cognitive Resilience to Alzheimer's Disease Pathology in the Human Brain.Journal of Alzheimer's disease : JAD · 2019Article
- Cognitive composite score association with Alzheimer's disease plaque and tangle pathology.Alzheimer's research & therapy · 2018Article
- Cognitive Domain Dispersion Association with Alzheimer's Disease Pathology.Journal of Alzheimer's disease : JAD · 2017Article
- Investigating the Usability and Acute Effects of a Bedside Video Console to Prefrontal Cortical Activity Alterations: A Preclinical Study in Healthy Elderly.Frontiers in systems neuroscience · 2017Article
- Molecular and cellular pathophysiology of preclinical Alzheimer's disease.Behavioural brain research · 2016Review
- Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly.Journal of Alzheimer's disease : JAD · 2016Article
- Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits.Neurobiology of aging · 2015Article
- Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle.NPJ aging and mechanisms of disease · 2015Article
- A 2-process model for neuropathology of Alzheimer's disease.Neurobiology of aging · 2014Article
- AD pathology and cerebral infarctions are associated with memory and executive functioning one and five years before death.Journal of clinical and experimental neuropsychology · 2013Article
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Abstract
Studies of neuropathology-cognition associations are not common and have been limited by small sample sizes, long intervals between autopsy and cognitive testing, and lack of breadth of neuropathology and cognition variables. This study examined domain-specific effects of common neuropathologies on cognition using data (N = 652) from two large cohort studies of older adults. We first identified dimensions of a battery of 17 neuropsychological tests, and regional measures of Alzheimer's disease (AD) neuropathology. We then evaluated how cognitive factors were related to dimensions of AD and additional measures of cerebrovascular and Lewy Body disease, and also examined independent effects of brain weight. All cognitive domains had multiple neuropathology determinants that differed by domain. Neocortical neurofibrillary tangles were the strongest predictors of most domains, while medial temporal tangles showed a weaker relationship with episodic memory. Neuritic plaques had relatively strong effects on multiple domains. Lewy bodies and macroscopic infarcts were associated with all domains, while microscopic infarcts had more limited associations. Brain weight was related to all domains independent of specific neuropathologies. Results show that cognition is complexly determined by multiple disease substrates. Neuropathological variables and brain weight contributed approximately a third to half of the explained variance in different cognitive domains.
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