ArticleInvestigative genetics2010
An epidemiological perspective on the future of direct-to-consumer personal genome testing.
Article in Investigative genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Internet-Based Direct-to-Consumer Genetic Testing: A Systematic Review.Journal of medical Internet research · 2015Pooled it
- Is This a Causal Relationship? Mendelian Randomization as a Statistical Method for Unraveling Connections.Arquivos brasileiros de cardiologia · 2024Article
- The Genetic Architecture of High Bone Mass.Frontiers in endocrinology · 2020Review
- Development of a general logistic model for disease risk prediction using multiple SNPs.FEBS open bio · 2019Article
- "I would rather have it done by a doctor"-laypeople's perceptions of direct-to-consumer genetic testing (DTC GT) and its ethical implications.Medicine, health care, and philosophy · 2019Article
- Medicine, market and communication: ethical considerations in regard to persuasive communication in direct-to-consumer genetic testing services.BMC medical ethics · 2018Article
- Medical Myths and Legends: Presidential Address to the Ulster Medical Society. 6th October 2016.The Ulster medical journal · 2018Article
- Attitudes to incorporating genomic risk assessments into population screening programs: the importance of purpose, context and deliberation.BMC medical genomics · 2016Article
- The impact of direct-to-consumer personal genomic testing on perceived risk of breast, prostate, colorectal, and lung cancer: findings from the PGen study.BMC medical genomics · 2015Article
- Direct to consumer testing in reproductive contexts--should health professionals be concerned?Life sciences, society and policy · 2015Article
- Design, methods, and participant characteristics of the Impact of Personal Genomics (PGen) Study, a prospective cohort study of direct-to-consumer personal genomic testing customers.Genome medicine · 2014Article
- Translational research policies: disruptions and continuities in biomedical innovation systems in Austria, Finland and Germany.Journal of community genetics · 2013Article
- Ethnicity, educational level and attitudes contribute to parental intentions about genetic testing for child obesity.Journal of community genetics · 2013Article
- Participant-Centric Initiatives: Tools to Facilitate Engagement In Research.Applied & translational genomics · 2012Article
- A randomized trial of genetic information for personalized nutrition.Genes & nutrition · 2012Article
- An exploration of genetic health professionals' experience with direct-to-consumer genetic testing in their clinical practice.European journal of human genetics : EJHG · 2012Article
- Personalised medicine: not just in our genes.BMJ (Clinical research ed.) · 2012Article
- Navigating a research partnership between academia and industry to assess the impact of personalized genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- The role of disease characteristics in the ethical debate on personal genome testing.BMC medical genomics · 2012Article
- Phenotype prediction from genome-wide association studies: application to smoking behaviors.BMC systems biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Personal genome testing is offered via the internet directly to consumers. Most tests that are currently offered use data from genome-wide scans to predict risks for multiple common diseases and traits. The utility of these tests is limited, predominantly because they lack predictive ability and clear benefits for disease prevention that are specific for genetic risk groups. In the near future, personal genome tests will likely be based on whole genome sequencing, but will these technological advances increase the utility of personal genome testing? Whole genome sequencing theoretically provides information about the risks of both monogenic and complex diseases, but the practical utility remains to be demonstrated. The utility of testing depends on the predictive ability of the test, the likelihood of actionable test results, and the options available for the reduction of risks. For monogenic diseases, the likelihood of known mutations will be extremely low in the general population and it will be a challenge to recognize new causal variants among all rare variants that are found using sequencing. For complex diseases, the predictive ability of genetic tests will be mainly restricted by the heritability of the disease, but also by the genetic complexity of the disease etiology, which determines the extent to which the heritability can be understood. Given that numerous genetic and non-genetic risk factors interact in the causation of complex diseases, the predictive ability of genetic models will likely remain modest. Personal genome testing will have minimal benefits for individual consumers unless major breakthroughs are made in the near future.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.