ArticleBMC cancer2010
Evaluation of FTIR spectroscopy as a diagnostic tool for lung cancer using sputum.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00899262 (Early Detection of Lung Cancer), which is not on this map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Lung Cancer: Metabolic Biomarkers for High Risk Screening (MEDLUNG)
Who cites it
53 citing papers in PubMed.
- Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer.Nature communications · 2019Trial
- Multimodal diagnostic network integrating infrared and mass spectra for lung cancer.Biomedical optics express · 2026Article
- Sputum Liquid Biopsy for Lung Cancer Screening, Diagnosis, Subtyping, Surveillance, Response Prediction, and Prognostication: A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- ATR-FTIR Spectroscopy of Saliva and Machine Learning as a Screening Test for Sjögren Disease.Analytical chemistry · 2025Article
- From Lab to Clinic: Artificial Intelligence with Spectroscopic Liquid Biopsies.Diagnostics (Basel, Switzerland) · 2025Review
- Serum and plasma as a good candidates of body fluids for detection lung cancer by FTIR liquid biopsy.Scientific reports · 2024Article
- Determination of platinum-resistance of women with ovarian cancer by FTIR spectroscopy combined with multivariate analyses and machine learning methods.Scientific reports · 2024Article
- Antifungal Activities of Biogenic Silver Nanoparticles Mediated by Marine Algae: In Vitro and In Vivo Insights of Coating Tomato Fruit to Protect againstMarine drugs · 2024Article
- Innovation in Non-Invasive Diagnosis and Disease Monitoring for Meningiomas.International journal of molecular sciences · 2024Review
- The Influence of the Nature of the Polymer Incorporating the Same AInternational journal of molecular sciences · 2023Article
- Non-Invasive Disease Specific Biomarker Detection Using Infrared Spectroscopy: A Review.Molecules (Basel, Switzerland) · 2023Review
- Liquid biopsies: the future of cancer early detection.Journal of translational medicine · 2023Review
- Fast and Deep Diagnosis Using Blood-Based ATR-FTIR Spectroscopy for Digestive Tract Cancers.Biomolecules · 2022Article
- Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy.Biomedicines · 2022Article
- Novel Thymoquinone Nanoparticles Using Poly(ester amide) Based on L-Arginine-Targeting Pulmonary Drug Delivery.Polymers · 2022Article
- Artificial neural network in the discrimination of lung cancer based on infrared spectroscopy.PloS one · 2022Article
- Detection of breast cancer by ATR-FTIR spectroscopy using artificial neural networks.PloS one · 2022Article
- Detection of ovarian cancer (± neo-adjuvant chemotherapy effects) via ATR-FTIR spectroscopy: comparative analysis of blood and urine biofluids in a large patient cohort.Analytical and bioanalytical chemistry · 2021Article
- Raman spectral cytopathology for cancer diagnostic applications.Nature protocols · 2021Article
- PLS-DA Model for the Evaluation of Attention Deficit and Hyperactivity Disorder in Children and Adolescents through Blood Serum FTIR Spectra.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvival time for lung cancer is poor with over 90% of patients dying within five years of diagnosis primarily due to detection at late stage. The main objective of this study was to evaluate Fourier transform infrared spectroscopy (FTIR) as a high throughput and cost effective method for identifying biochemical changes in sputum as biomarkers for detection of lung cancer.
methodsSputum was collected from 25 lung cancer patients in the Medlung observational study and 25 healthy controls. FTIR spectra were generated from sputum cell pellets using infrared wavenumbers within the 1800 to 950 cm-1 "fingerprint" region.
resultsA panel of 92 infrared wavenumbers had absorbances significantly different between cancer and normal sputum spectra and were associated with putative changes in protein, nucleic acid and glycogen levels in tumours. Five prominent significant wavenumbers at 964 cm-1, 1024 cm-1, 1411 cm-1, 1577 cm-1 and 1656 cm-1 separated cancer spectra from normal spectra into two distinct groups using multivariate analysis (group 1: 100% cancer cases; group 2: 92% normal cases). Principal components analysis revealed that these wavenumbers were also able to distinguish lung cancer patients who had previously been diagnosed with breast cancer. No patterns of spectra groupings were associated with inflammation or other diseases of the airways.
conclusionsOur results suggest that FTIR applied to sputum might have high sensitivity and specificity in diagnosing lung cancer with potential as a non-invasive, cost-effective and high-throughput method for screening.
trial registrationClinicalTrials.gov: NCT00899262.
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