ArticleImmunome research2010
DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells.
Article in Immunome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.Frontiers in immunology · 2018Review
- Informatics for cancer immunotherapy.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Review
- Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response.BioMed research international · 2016Article
- Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease.Journal of immunology research · 2016Review
- Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps.Oncogenesis · 2015Article
- Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines.Nature communications · 2014Article
- Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals.Beilstein journal of organic chemistry · 2014Article
- Bioinformatic approaches for functional annotation and pathway inference in metagenomics data.Briefings in bioinformatics · 2012Review
- Systems biology of host-fungus interactions: turning complexity into simplicity.Current opinion in microbiology · 2012Review
- Identifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells.Infection and immunity · 2012Article
- Article
- The Biological Connection Markup Language: a SBGN-compliant format for visualization, filtering and analysis of biological pathways.Bioinformatics (Oxford, England) · 2011Article
- Systems biology approaches to toll-like receptor signaling.Wiley interdisciplinary reviews. Systems biology and medicineArticle
Corrections and comments
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Authors and funding
38 authors.
Funding
Abstract
backgroundThe advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell type specificity of the reactions is the foundation of immunological research, and capturing this specificity is of paramount importance when using pathway-based analyses to decipher complex immunological datasets. Here, we present DC-ATLAS, a novel and versatile resource for the interpretation of high-throughput data generated perturbing the signaling network of dendritic cells (DCs).
resultsPathways are annotated using a novel data model, the Biological Connection Markup Language (BCML), a SBGN-compliant data format developed to store the large amount of information collected. The application of DC-ATLAS to pathway-based analysis of the transcriptional program of DCs stimulated with agonists of the toll-like receptor family allows an integrated description of the flow of information from the cellular sensors to the functional outcome, capturing the temporal series of activation events by grouping sets of reactions that occur at different time points in well-defined functional modules.
conclusionsThe initiative significantly improves our understanding of DC biology and regulatory networks. Developing a systems biology approach for immune system holds the promise of translating knowledge on the immune system into more successful immunotherapy strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.