ArticleThe European journal of neuroscience2011
Light-evoked synaptic activity of retinal ganglion and amacrine cells is regulated in developing mouse retina.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Light drives the developmental progression of outer retinal function.The Journal of general physiology · 2023Article
- Graphene-based microfluidic perforated microelectrode arrays for retinal electrophysiological studies.Lab on a chip · 2023Article
- Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells.Frontiers in cellular neuroscience · 2021Article
- Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina.Scientific reports · 2017Article
- Increased proliferation of late-born retinal progenitor cells by gestational lead exposure delays rod and bipolar cell differentiation.Molecular vision · 2016Article
- Compensatory plasticity in the olfactory epithelium: age, timing, and reversibility.Journal of neurophysiology · 2015Article
- Refinement but not maintenance of visual receptive fields is independent of visual experience.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Developmental changes in NMDA receptor subunit composition at ON and OFF bipolar cell synapses onto direction-selective retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Distribution and development of P2Y1-purinoceptors in the mouse retina.Journal of molecular histology · 2013Article
- Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.PloS one · 2013Article
- Article
- Postsynaptic current bursts instruct action potential firing at a graded synapse.Nature communications · 2013Article
- Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina.Developmental neurobiology · 2012Article
- Developmental mechanisms that regulate retinal ganglion cell dendritic morphology.Developmental neurobiology · 2011Article
- Receptive field center size decreases and firing properties mature in ON and OFF retinal ganglion cells after eye opening in the mouse.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent studies have shown a continued maturation of visual responsiveness and synaptic activity of retina after eye opening, including the size of receptive fields of retinal ganglion cells (RGCs), light-evoked synaptic output of RGCs, bipolar cell spontaneous synaptic inputs to RGCs, and the synaptic connections between RGCs and ON and OFF bipolar cells. Light deprivation retarded some of these age-dependent changes. However, many other functional and morphological features of RGCs are not sensitive to visual experience. To determine whether light-evoked synaptic responses of RGCs undergo developmental change, we directly examined the light-evoked synaptic inputs from ON and OFF synaptic pathways to RGCs in developing retinas, and found that both light-evoked excitatory and inhibitory synaptic currents decreased, but not increased, with age. We also examined the light-evoked synaptic inputs from ON and OFF synaptic pathways to amacrine cells in developing retinas and found that the light-evoked synaptic input of amacrine cells is also downregulated in developing mouse retina. Different from the developmental changes of RGC spontaneous synaptic activity, dark rearing has little effect on the developmental changes of light-evoked synaptic activity of both RGCs and amacrine cells. Therefore, we concluded that the synaptic mechanisms mediating spontaneous and light-evoked synaptic activity of RGCs and amacrine cells are likely to be different.
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