ArticleCellular microbiology2011
Attenuation of host NO production by MAMPs potentiates development of the host in the squid-vibrio symbiosis.
Article in Cellular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Function and Development of Deep-sea Mussel Bacteriocytes Revealed by snRNA-seq and Spatial Transcriptomics.Genomics, proteomics & bioinformatics · 2026Article
- Strain matters: host responses reflect symbiont origin in the squid-vibrio symbiosis.mSystems · 2025Article
- Cephalopod-omics: Emerging Fields and Technologies in Cephalopod Biology.Integrative and comparative biology · 2023Article
- Symbiont coordinates stem cell proliferation, apoptosis, and morphogenesis of gut symbiotic organ in the stinkbug-Frontiers in physiology · 2022Article
- Inhibitory Effect of FMRFamide on NO Production During Immune Defense inFrontiers in immunology · 2022Article
- A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner.Nature reviews. Microbiology · 2021Review
- Article
- Reports from a Healthy Community: The 7th Conference on Beneficial Microbes.Applied and environmental microbiology · 2018Review
- Bacterial symbionts use a type VI secretion system to eliminate competitors in their natural host.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- D-fining DarR: a LysR-type transcriptional regulator that responds to D-aspartate.Journal of bacteriology · 2018Article
- Transcriptomic changes in an animal-bacterial symbiosis under modeled microgravity conditions.Scientific reports · 2017Article
- Environmental cues and symbiont microbe-associated molecular patterns function in concert to drive the daily remodelling of the crypt-cell brush border of the Euprymna scolopes light organ.Cellular microbiology · 2016Article
- A conserved chemical dialog of mutualism: lessons from squid and vibrio.Microbes and infection · 2016Review
- Impact and Influence of the NaturalFrontiers in microbiology · 2016Review
- Lipopolysaccharides from Commensal and Opportunistic Bacteria: Characterization and Response of the Immune System of the Host Sponge Suberites domuncula.Marine drugs · 2015Article
- Transcriptome analysis of the white body of the squid Euprymna tasmanica with emphasis on immune and hematopoietic gene discovery.PloS one · 2015Article
- The oxidative environment: a mediator of interspecies communication that drives symbiosis evolution.Proceedings. Biological sciences · 2014Review
- Host-microbe interactions in microgravity: assessment and implications.Life (Basel, Switzerland) · 2014Review
- Extensive differences in gene expression between symbiotic and aposymbiotic cnidarians.G3 (Bethesda, Md.) · 2014Article
- Eye-specification genes in the bacterial light organ of the bobtail squid Euprymna scolopes, and their expression in response to symbiont cues.Mechanisms of development · 2014Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Bacterial pathogens typically upregulate the host's production of nitric oxide synthase (NOS) and nitric oxide (NO) as antimicrobial agents, a response that is often mediated by microbe-associated molecular patterns (MAMPs) of the pathogen. In contrast, previous studies of the beneficial Euprymna scolopes/Vibrio fischeri symbiosis demonstrated that symbiont colonization results in attenuation of host NOS/NO, which occurs in high levels in hatchling light organs. Here, we sought to determine whether V. fischeri MAMPs, specifically lipopolysaccharide (LPS) and the peptidoglycan derivative tracheal cytotoxin (TCT), attenuate NOS/NO, and whether this activity mediates the MAMPs-induced light organ morphogenesis. Using confocal microscopy, we characterized levels of NOS with immunocytochemistry and NO with a NO-specific fluorochrome. When added exogenously to seawater containing hatchling animals, V. fischeri LPS and TCT together, but not individually, induced normal NOS/NO attenuation. Further, V. fischeri mutants defective in TCT release did not. Experiments with NOS inhibitors and NO donors provided evidence that NO mediates apoptosis and morphogenesis associated with symbiont colonization. Attenuation of NOS/NO by LPS and TCT in the squid-vibrio symbiosis provides another example of how the host's response to MAMPs depends on the context. These data also provide a mechanism by which symbiont MAMPs regulate host development.
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