ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2011
Effect of obesity on asthma phenotype is dependent upon asthma severity.
Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- Overweight, Obesity, and Lung Function in Children and Adults-A Meta-analysis.The journal of allergy and clinical immunology. In practicePooled it
- Unsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles.Diagnostics (Basel, Switzerland) · 2025Article
- The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset.Scientific reports · 2024Article
- ERS International Congress 2023: highlights from the Paediatrics Assembly.ERJ open research · 2024Article
- Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life.The World Allergy Organization journal · 2023Article
- Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Metformin Alleviates Airway Hyperresponsiveness in a Mouse Model of Diet-Induced Obesity.Frontiers in physiology · 2022Article
- Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet.Scientific reports · 2019Article
- Evaluation and treatment of critical asthma syndrome in children.Clinical reviews in allergy & immunology · 2015Review
- Abdominal adiposity and obstructive airway disease: testing insulin resistance and sleep disordered breathing mechanisms.BMC pulmonary medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe recently reported that obese and non-obese patients with asthma have similar airflow limitation and bronchodilator responsiveness, but obese patients have more symptoms overall. There is limited information on the effect of obesity on asthmatics of varying severity measured by objective physiological parameters. Understanding how obesity affects asthmatics of differing severity can provide insights into the pathogenesis of asthma in the obese and a rationale for the therapeutic approach to such patients.
methodsParticipants with asthma from two American Lung Association--Asthma Clinical Research Center (ALA-ACRC) studies were grouped by tertiles of airflow obstruction (forced expiratory volume in one second (FEV(1)%) predicted, FEV(1)/forced vital capacity (FVC)) and methacholine reactivity (PC(20)FEV(1)). Within each tertile, we examined the independent effect of body mass index (BMI), divided into normal weight, overweight, and obese categories, on lung function, airway reactivity, and symptoms.
resultsOverall, both FEV(1) and FVC decreased and symptoms worsened with increasing BMI; airway reactivity was unchanged. When stratified by the degree of airflow obstruction, higher BMI was not associated with greater airway reactivity to methacholine. Higher BMI was associated with more asthma symptoms only in the least obstructed FEV(1)/FVC tertile. When stratified by degree of airway reactivity, BMI was inversely associated with FVC in all PC(20)FEV(1) tertiles. BMI was directly associated with asthma symptoms only in those with the least airway reactivity.
conclusionsObesity does not influence airway reactivity in patients with asthma and it is associated with more symptoms only in those with less severe disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.