Evidence map›Paper›PMID 21091078›Full record

ReviewAntioxidants & redox signaling2011

Radiation as a risk factor for cardiovascular disease.

John E Baker, John E Moulder, John W Hopewell

Open access · hybridAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 117 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Low-dose Radiation Therapy (LDRT) in Managing Osteoarthritis: A Comprehensive Review.Current therapeutic research, clinical and experimental · 2025
    Review
  6. Observational
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Radiation-Induced Heart Disease.Journal of clinical medicine · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Long-term spaceflight and the cardiovascular system.Precision clinical medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

John E BakerDivision of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. jbaker@mcw.edu
John E Moulder
John W Hopewell
Children's Hospital of Wisconsin · USMedical College of Wisconsin · USUniversity of Oxford · GB

Funding

Training and educationU19AI067734 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MOULDER, JOHN E · 2005 to 2009
$18.2M
NITRIC OXIDE AND TOLERANCE OF HYPOXIC HEART TO ISCHEMIAR01HL054075 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BAKER, JOHN E · 1997 to 2010
$2.5M
Radiation injury to the heartR01AI080363 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI BAKER, JOHN E · 2009 to 2010
$760k
NHLBI NIH HHS HL54075NIAID NIH HHS AI067734NIAID NIH HHS AI080363
6 · The paper itself

Abstract

Abstract population are ubiquitous background radiation and medical exposure of patients. From the early 1980s to 2006, the average dose per individual in the United States for all sources of radiation increased by a factor of 1.7-6.2 mSv, with this increase due to the growth of medical imaging procedures. Radiation can place individuals at an increased risk of developing cardiovascular disease. Excess risk of cardiovascular disease occurs a long time after exposure to lower doses of radiation as demonstrated in Japanese atomic bomb survivors. This review examines sources of radiation (atomic bombs, radiation accidents, radiological terrorism, cancer treatment, space exploration, radiosurgery for cardiac arrhythmia, and computed tomography) and the risk for developing cardiovascular disease. The evidence presented suggests an association between cardiovascular disease and exposure to low-to-moderate levels of radiation, as well as the well-known association at high doses. Studies are needed to define the extent that diagnostic and therapeutic radiation results in increased risk factors for cardiovascular disease, to understand the mechanisms involved, and to develop strategies to mitigate or treat radiation-induced cardiovascular disease.

Indexed as

AnimalsCardiovascular DiseasesChernobyl Nuclear AccidentEnvironmental ExposureHumansLipid MetabolismRadiation InjuriesRadiation Injuries, ExperimentalRadiation ToleranceRadiographyRadiotherapyRisk FactorsSpace FlightTerrorismWhole-Body Irradiation

Identifiers

PMID21091078
PMCPMC3159113
OpenAlexW2068510084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.