ArticleJournal of clinical laboratory analysis2010
Predictive values of neutrophil CD64 expression compared with interleukin-6 and C-reactive protein in early diagnosis of neonatal sepsis.
Article in Journal of clinical laboratory analysis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- A meta-analysis of interleukin-6 as a valid and accurate index in diagnosing early neonatal sepsis.International wound journal · 2019Pooled it
- Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis.Italian journal of pediatrics · 2016Pooled it
- Diagnosis of neonatal sepsis: the past, present and future.Pediatric research · 2022Review
- Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers.Frontiers in pediatrics · 2022Review
- The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis.International journal of microbiology · 2020Article
- Can Base Excess be Used for Prediction to Early Diagnosis of Neonatal Sepsis in Preterm Newborns?Mediterranean journal of hematology and infectious diseases · 2019Article
- Utility of presepsin, soluble triggering receptor expressed on myeloid cells-1, and neutrophil CD64 for early detection of neonatal sepsis.Infection and drug resistance · 2019Article
- Examining the utility of the CD64 index compared with other conventional indices for early diagnosis of neonatal infection.Scientific reports · 2018Article
- Could Neutrophil CD64 Expression Be Used as a Diagnostic Parameter of Bacteremia in Patients with Febrile Neutropenia?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017Article
- Neutrophil CD64 as a diagnostic marker of sepsis: impact on neonatal care.American journal of perinatology · 2015Article
- Mean platelet volume and uric acid levels in neonatal sepsis.Indian journal of pediatrics · 2014Article
- Neutrophil CD64 expression is a predictor of mortality for patients in the intensive care unit.International journal of clinical and experimental pathology · 2014Article
- Flow cytometry in the detection of neonatal sepsis.International journal of pediatrics · 2013Article
- Which biomarkers reveal neonatal sepsis?PloS one · 2013Article
- Neutrophil CD64 as a diagnostic marker in neonatal sepsis.The Pediatric infectious disease journal · 2012Article
- Neonatal sepsis: Role of a battery of immunohematological tests in early diagnosis.International journal of applied & basic medical research · 2012Article
- Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis.Korean journal of pediatrics · 2012Article
- DNA methylation: an epigenetic risk factor in preterm birth.Reproductive sciences (Thousand Oaks, Calif.) · 2012Review
- Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions.Critical care (London, England) · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite major advances in the management of newborn infants, neonatal sepsis (NS) remain important causes of neonatal morbidity and mortality in the newborn, mainly among preterm and low birth weight infants.
objectiveThe aim of this study was to investigate the usefulness of neutrophil CD64 expression alone and together with other infection markers in NS.
methodsPeripheral blood samples were taken from 109 neonates, who were categorized into three groups: proven or clinical sepsis (n=35); disease without infection (n=42); and healthy controls (n=32). Complete blood count with differential, interleukin-6 (IL-6), C-reactive protein (CRP), and cell surface expression of CD64 on neutrophils have been evaluated in a prospective manner as a diagnostic aid for NS.
resultsExpression of CD64 was significantly enhanced in neonates with sepsis compared with newborns with disease without infection and healthy controls (P=0.001 and P=0.001, respectively). Cutoff values of IL-6, CRP, CD64(MFI), and CD64(i) were 24.9 pg/ml, 4.05 mg/l, 87.7, and 4.39, respectively. Sensitivity-negative predictive values of IL-6, CRP, and CD64(MFI)/CD64(i) were 80.0-90.6%, 80.0-88.8%, and 88.6-94.0%, respectively. Combining all three tests increased the sensitivity to 100%; however, specificity and positive predictive value decreased to 62.1 and 55.5%, respectively.
conclusionsCD64 might be used either alone or combined with IL-6 and CRP for early diagnosis of NS. The advantages of CD64 when compared with IL-6 and CRP are rapid quantitation, very small blood volume required, and easy handling.
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