ArticleStem cells (Dayton, Ohio)2010
Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus.
Article in Stem cells (Dayton, Ohio), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- APC in the nervous system.Medical molecular morphology · 2026Review
- Disease-specific alterations of the enteric nervous system in precancerous colonic mucosa and their implications for mucin regulation.Scientific reports · 2025Article
- Two independent families with de novo whole APC gene deletion and intellectual disability: a case report.Hereditary cancer in clinical practice · 2025Article
- Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.Molecular neurobiology · 2019Article
- Multiple roles of Ulk4 in neurogenesis and brain function.Neurogenesis (Austin, Tex.) · 2017Article
- Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS.Development (Cambridge, England) · 2016Article
- Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis.Scientific reports · 2016Article
- Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus.Scientific reports · 2016Article
- Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone.Neurochemical research · 2016Review
- Differences in neuropsychological and behavioral parameters and brain structure in patients with familial adenomatous polyposis: a sibling-paired study.Hereditary cancer in clinical practice · 2016Article
- Canonical and noncanonical Wnt signaling in neural stem/progenitor cells.Cellular and molecular life sciences : CMLS · 2015Review
- Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development.PloS one · 2015Article
- Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus.Frontiers in neuroscience · 2014Article
- Role of wnt signaling in the control of adult hippocampal functioning in health and disease: therapeutic implications.Current neuropharmacology · 2013Article
- Physiological role of β-catenin/TCF signaling in neurons of the adult brain.Neurochemical research · 2013Review
- Adenomatous polyposis coli regulates oligodendroglial development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Wnt signaling regulates postembryonic hypothalamic progenitor differentiation.Developmental cell · 2012Article
- Progenitor expansion in apc mutants is mediated by Jak/Stat signaling.BMC developmental biology · 2011Article
- WNT protein-independent constitutive nuclear localization of beta-catenin protein and its low degradation rate in thalamic neurons.The Journal of biological chemistry · 2011Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The tumor suppressor adenomatous polyposis coli (APC) is a multifunctional protein that not only inhibits the Wnt signaling pathway by promoting the degradation of β-catenin but also controls cell polarity, motility, and division. APC is abundantly expressed in the adult central nervous system, but its role in adult neurogenesis remains unknown. Using conditional deletion (or knockout) of APC (APC-CKO) from glial fibrillary acidic protein (GFAP)-expressing cells including adult neural stem cells (NSCs) in the subventricular zone and hippocampal dentate gyrus, we show that APC expression by these cells is a critical component of adult neurogenesis. Loss of APC function resulted in a marked reduction of GFAP-expressing NSC-derived new neurons, leading to the decreased volume of olfactory granule cell layer. Two distinct mechanisms account for impaired neurogenesis in APC-CKO mice. First, APC was highly expressed in migrating neuroblasts and APC deletion disturbed the differentiation from Mash1-expressing transient amplifying cells to neuroblasts with concomitant accumulation of β-catenin. As a result, migrating neuroblasts decreased, whereas Mash1-expressing dividing cells reciprocally increased in the olfactory bulb of APC-CKO mice. Second, APC deletion promoted an exhaustion of the adult germinal zone. Functional NSCs and their progeny progressively depleted with age. These findings demonstrate that APC expression plays a key role in regulating intracellular β-catenin level and neuronal differentiation of newly generated cells, as well as maintaining NSCs in the adult neurogenic niche. STEM CELLS 2010;28:2053-2064.
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