Evidence map›Paper›PMID 21088974›Full record

ReviewLangenbeck's archives of surgery2011

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences.

Brigitte Vollmar, Michael D Menger

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Langenbeck's archives of surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02408939 (Effect of Stress-dose Steroids on Post-resuscitation Infectious), which is not on this map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02408939 completednot on this mapstarted 2015, after this paper: background citation

Effect of Stress-dose Steroids on Post-resuscitation Infectious (Septic) Complications After In-hospital Cardiac Arrest. Individual Patient Data-based Re-analysis of Synthesized Prior Randomized Clinical Trial Data

TypeobservationalSponsorUniversity of AthensRan2015 to 2015Enrolled191ConditionsInfections, Cardiac ArrestArmsStress-dose hydrocortisone
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Fraxin as a promising molecule in the pharmacological treatment of acute mesenteric ischemia: an experimental study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brigitte VollmarInstitute for Experimental Surgery, University of Rostock, Schillingallee 69a, 18055, Rostock, Germany. brigitte.vollmar@med.uni-rostock.de
Michael D Menger

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntestinal ischemia and reperfusion (I/R) is a challenging and life-threatening clinical problem with diverse causes. The delay in diagnosis and treatment contributes to the continued high in-hospital mortality rate.

resultsExperimental research during the last decades could demonstrate that microcirculatory dysfunctions are determinants for the manifestation and propagation of intestinal I/R injury. Key features are nutritive perfusion failure, inflammatory cell response, mediator surge and breakdown of the epithelial barrier function with bacterial translocation, and development of a systemic inflammatory response. This review provides novel insight into the basic mechanisms of damaged intestinal microcirculation and covers therapeutic targets to attenuate intestinal I/R injury.

conclusionThe opportunity now exists to apply this insight into the translation of experimental data to clinical trial-based research. Understanding the basic events triggered by intestinal I/R may offer new diagnostic and therapeutic options in order to achieve improved outcome of patients with intestinal I/R injury.

Indexed as

AnimalsBacterial TranslocationDiagnosis, DifferentialDisseminated Intravascular CoagulationEarly DiagnosisHumansInflammation MediatorsIntestinal AbsorptionIntestinal MucosaIntestinesIschemiaIschemic PreconditioningMesenteric Vascular OcclusionMesenteryMicrocirculationPrognosisInflammation Mediators

Identifiers

PMID21088974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.