ArticlePsychopharmacology2011
Selective breeding for magnitude of methamphetamine-induced sensitization alters methamphetamine consumption.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.Neurotoxicity research · 2023Article
- A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects.Molecular psychiatry · 2022Article
- A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.Genes, brain, and behavior · 2021Article
- Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).Behavior genetics · 2018Article
- Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats.Psychopharmacology · 2017Article
- Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly.Biological psychiatry · 2017Article
- Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug.Psychopharmacology · 2016Article
- Swimming exercise attenuates psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats.Iranian journal of basic medical sciences · 2016Article
- An animal model of differential genetic risk for methamphetamine intake.Frontiers in neuroscience · 2015Review
- Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice.Addiction biology · 2014Article
- Luteolin inhibits behavioral sensitization by blocking methamphetamine-induced MAPK pathway activation in the caudate putamen in mice.PloS one · 2014Article
- Genetic factors involved in risk for methamphetamine intake and sensitization.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.Behavioural brain research · 2013Article
- Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats.Behavior genetics · 2013Article
- Effects of sodium butyrate on methamphetamine-sensitized locomotor activity.Behavioural brain research · 2013Article
- Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.PloS one · 2013Article
- Behavioral inhibition in mice bred for high vs. low levels of methamphetamine consumption or sensitization.Psychopharmacology · 2012Article
- Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA.Neuron · 2012Article
- Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
rationaleGenetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption.
objectivesStudies were performed to determine whether selective breeding could be used to create lines of mice with different magnitudes of locomotor sensitization to methamphetamine (MA). MA sensitization (MASENS) lines were also examined for genetically correlated responses to MA.
methodsBeginning with the F2 cross of C57BL/6J and DBA/2J strains, mice were tested for locomotor sensitization to repeated injections of 1 mg/kg MA and bred based on magnitude of sensitization. Five selected offspring generations were tested. All generations were also tested for MA consumption, and some were tested for dose-dependent locomotor-stimulant responses to MA, consumption of saccharin, quinine, and potassium chloride as a measure of taste sensitivity, and MA clearance after acute and repeated MA.
resultsSelective breeding resulted in creation of two lines [MA high sensitization (MAHSENS) and MA low sensitization (MALSENS)] that differed in magnitude of MA-induced sensitization. Initially, greater MA consumption in MAHSENS mice reversed over the course of selection so that MALSENS mice consumed more MA. MAHSENS mice exhibited greater sensitivity to the acute stimulant effects of MA, but there were no significant differences between the lines in MA clearance from blood.
conclusionsGenetic factors influence magnitude of MA-induced locomotor sensitization and some of the genes involved in magnitude of this response also influence MA sensitivity and consumption. Genetic factors leading to greater MA-induced sensitization may serve a protective role against high levels of MA consumption.
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