ArticleJournal of neurology2011
Comparison of muscle ultrastructure in myasthenia gravis with anti-MuSK and anti-AChR antibodies.
Article in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Evaluation of plasma neurofilament light chain and glial fibrillary acidic protein in myasthenia gravis: A controlled cohort study.PloS one · 2026Article
- Mitochondrial proteins contribute to the pathogenesis of myasthenia gravis.Scientific reports · 2025Article
- Clinicopathological profiling and prognosis of idiopathic inflammatory myopathy overlapping with myasthenia gravis: a retrospective cohort study.Journal of neurology · 2025Article
- Mitochondrial dysfunction in myasthenia gravis: Exploring directions for future immunotherapy? A review.Biomolecules & biomedicine · 2025Review
- Myasthenia gravis with double-seropositive acetylcholine receptor and low-density lipoprotein receptor-related protein 4 antibodies combined with muscle atrophy: a case report and literature review.Frontiers in immunology · 2025Review
- Relationship between fatigue and quantitative electromyography findings in patients with myasthenia gravis.Heliyon · 2024Article
- Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives.Pharmaceutics · 2024Review
- Is paravertebral muscles edema a consequence of neurogenic changes in MuSK-positive myasthenia gravis?Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2022Article
- Serum neurofilament light chain in myasthenia gravis subgroups: An exploratory cohort and case-Control study.Frontiers in neurology · 2022Article
- Muscle-Specific Kinase Myasthenia Gravis.Frontiers in immunology · 2020Review
- PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats.Scientific reports · 2018Article
- Muscle-Specific Tyrosine Kinase and Myasthenia Gravis Owing to Other Antibodies.Neurologic clinics · 2018Review
- The Myotonic Plot Thickens: Electrical Myotonia in Antimuscle-Specific Kinase Myasthenia Gravis.Case reports in neurological medicine · 2015Article
- Article
- Animal models of antimuscle-specific kinase myasthenia.Annals of the New York Academy of Sciences · 2012Article
- Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis.Journal of neurology · 2012Article
- Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster.PloS one · 2012Article
- Disease-specific divergence of inflammatory and metabolic biomarkers in neurocritical neuromuscular disorders.Frontiers in neurologyArticle
Corrections and comments
- Erratum issuedValentina, Papa [corrected to Papa, Valentina]; Marina, Fanin [corrected to Fanin, Marina]; Elena, Pegoraro [corrected to Pegoraro, Elena]; Corrado, Angelini [corrected to Angelini, Corrado]
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with myasthenia gravis (MG) with antibodies to muscle-specific receptor tyrosine kinase (MuSK) differ from acetylcholine receptor (AChR)-positive MG patients, as they frequently present with severe oculobulbar muscle weakness or with neck, shoulder, and respiratory muscle involvement. The neuromuscular junction (NMJ) has been confirmed to be the main target of both AChR- and MuSK-MG. However, histopathological investigation disclosed that muscle fiber atrophy was prevalent in AChR-MG, whereas mild myopathic changes and mitochondrial abnormalities were more frequently observed in MuSK-MG. As the pathogenetic mechanism in MuSK-MG remains unclear, this study investigated the submicroscopic pattern of muscle histopathology to establish a possible correlation between clinical involvement and subcellular morphological findings. Muscle biopsies from seven MuSK-MG patients and from seven patients with AChR-MG were analyzed by transmission electron microscopy. Myopathic and mitochondrial abnormalities were more prominent in MuSK-MG and show giant, swollen, and degenerated mitochondria with fragmented cristae. The most common changes in AChR-MG muscles were fiber atrophy, myofibrillar disarray, and Z-line streaming, consistent with mild neurogenic abnormalities. A different pathogenetic mechanism is emerging in MuSK-MG compared to AChR-MG. Mitochondrial abnormalities seem to be more prominent in MuSK-MG, whereas neurogenic atrophy is observed in AChR-MG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.