ArticleKorean circulation journal2010
Hyponatremia and syndrome of inappropriate antidiuretic hormone secretion in kawasaki disease.
Article in Korean circulation journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Association between sodium content of intravenous immunoglobulin and electrolyte changes and clinical course of Kawasaki disease.Clinical and experimental pediatrics · 2026Article
- Hyponatremia upon PICU admission: a 10-year retrospective analysis of outcomes and independent prognostic value.BMC pediatrics · 2026Observational
- Uncommon coexistence of giant cell arteritis and SIADH: case reports and literature review.Internal and emergency medicine · 2026Article
- Article
- Recurrent Kawasaki disease with polyserositis and pulmonary lesions in a 5-year-old boy: a case report.Frontiers in pediatrics · 2025Article
- The Different Paths That Lead to Hypotonic Hyponatremia, and a Safe Approach to Treatment.Journal of clinical medicine · 2024Review
- Role of Pyroptosis in IVIG-Resistant Kawasaki Disease and the Establishment of a New Predictive Model.Journal of inflammation research · 2024Article
- Concomitant Kawasaki Disease and Rotavirus Infection-More Than Just a Coincidence: A Case Report.Tropical medicine and infectious disease · 2023Article
- The prevalence and outcomes of hyponatremia in children with COVID-19 and multisystem inflammatory syndrome in children (MIS-C).Frontiers in pediatrics · 2023Article
- Ultrasound evaluation of endothelial dysfunction in immunoglobulin-resistant children with acute Kawasaki disease.Clinical rheumatology · 2022Article
- Serum sodium level associated with coronary artery lesions in patients with Kawasaki disease.Clinical rheumatology · 2022Article
- Sodium-containing versus sodium-trace preparations of IVIG for children with Kawasaki disease in the acute phase.European journal of pediatrics · 2021Article
- Usefulness of Kawasaki disease risk scoring systems to the Turkish population.Anatolian journal of cardiology · 2020Article
- Article
- Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study.Open access rheumatology : research and reviews · 2020Article
- A Case of Kawasaki Disease Complicated With Cerebral Salt-Wasting Syndrome.Frontiers in pediatrics · 2020Article
- A New Scoring System for Prediction of Intravenous Immunoglobulin Resistance of Kawasaki Disease in Infants Under 1-Year Old.Frontiers in pediatrics · 2019Article
- Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease.Korean journal of pediatrics · 2017Article
- Influenza as a Cause of SIADH Related Hyponatremia: A Case Report.Journal of clinical and diagnostic research : JCDR · 2017Article
- The Efficacy and Safety of High-Dose Intravenous Immunoglobulin in the Treatment of Kawasaki Disease: How Can We Predict Resistance to Intravenous Immunoglobulin Treatment of Kawasaki Disease?Korean circulation journal · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe pathogenesis of hyponatremia (serum sodium <135 mEq/L) in Kawasaki disease (KD) remains unclear. We investigated the clinical significance of hyponatremia, and the role of interleukin (IL)-6 and IL-1β in the development of hyponatremia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) in KD. SUBJECTS AND
methodsFifty KD patients were prospectively enrolled and analyzed for clinical and laboratory variables according to the presence of hyponatremia or SIADH.
resultsThirteen KD patients (26%) had hyponatremia and 6 of these had SIADH. In patients with hyponatremia, the percentage of neutrophils (% neutrophils), C-reactive protein (CRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were higher than in those without hyponatremia, while serum triiodothyronine (T3) and albumin were lower. Patients with hyponatremia had a higher incidence of intravenous immunoglobulin-resistance but this was not statistically significant. No differences existed between patients with and without SIADH with regard to clinical or laboratory variables and the incidence of IVIG-resistance. Serum sodium inversely correlated with % neutrophils, CRP, and NT-proBNP, and positively correlated with T3 and albumin. Serum IL-6 and IL-1β levels increased in KD patients and were higher in patients with hyponatremia. Plasma antidiuretic hormone increased in patients with SIADH, which tended to positively correlate with IL-6 and IL-1β levels.
conclusionHyponatremia occurs in KD patients with severe inflammation, while increased IL-6 and IL-1β may activate ADH secretion, leading to SIADH and hyponatremia in KD.
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