Evidence map›Paper›PMID 21088682›Full record

ReviewNature reviews. Immunology2010

The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.

Shannon J Turley, Anne L Fletcher, Kutlu G Elpek

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 156 citations in OpenAlex.

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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shannon J TurleyDepartment of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA. shannon_turley@dfci.harvard.edu
Anne L Fletcher
Kutlu G Elpek
Dana-Farber Cancer Institute · USBoston University · US

Funding

TCR recognition of MHC class II peptide compexes in multiple sclerosisP01AI045757 · NIAID · DANA-FARBER CANCER INSTITUTE · PI WUCHERPFENNIG, KAI W · 1999 to 2017
$22.8M
Role of the gut epithelium in pancreatic autoimmunityR01DK074500 · NIDDK · DANA-FARBER CANCER INST · PI HAINING, WILLIAM NICHOLAS · 2007 to 2016
$3.4M
NIAID NIH HHS P01 AI045757NIDDK NIH HHS R01 DK074500
6 · The paper itself

Abstract

T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.

Indexed as

AnimalsAntigen-Presenting CellsAntigensCell MovementHematopoietic SystemHumansImmune ToleranceLymphoid TissueMiceStromal CellsT-LymphocytesAntigens

Identifiers

PMID21088682
OpenAlexW2011186939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.