ArticleThe EMBO journal1990
In vivo transformation of factor-dependent hemopoietic cells: role of intracisternal A-particle transposition for growth factor gene activation.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- Reversible growth factor dependency and autonomy during murine myelomonocytic leukemia induced by oncogenes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- RasGRP Ras guanine nucleotide exchange factors in cancer.Frontiers in biology · 2013Article
- Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.Nature genetics · 2011Article
- The colony-stimulating factors and cancer.Nature reviews. Cancer · 2010Review
- The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.Journal of virology · 2001Article
- Pigment, platelets, and Hermansky-Pudlak in human and mouse.Proceedings of the National Academy of Sciences of the United States of America · 1997Review
- Germ line-specific expression of intracisternal A-particle retrotransposons in transgenic mice.Molecular and cellular biology · 1996Article
- Co-amplification to tail-to-tail copies of MuRVY and IAPE retroviral genomes on the Mus musculus Y chromosome.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- The tight-skin (Tsk) mutation is closely linked to B2m on mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- The intracisternal A-particle upstream element interacts with transcription factor YY1 to activate transcription: pleiotropic effects of YY1 on distinct DNA promoter elements.Molecular and cellular biology · 1993Article
- Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.The EMBO journal · 1993Article
- Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene.The Journal of experimental medicine · 1993Article
- High-frequency intracellular transposition of a defective mammalian provirus detected by an in situ colorimetric assay.Journal of virology · 1992Article
- Selective activation of a discrete family of endogenous proviral elements in normal BALB/c lymphocytes.Molecular and cellular biology · 1992Article
- Intracisternal A-type particle-mediated activations of cytokine genes in a murine myelomonocytic leukemia: generation of functional cytokine mRNAs by retroviral splicing events.Molecular and cellular biology · 1991Article
- An indicator gene for detection of germline retrotransposition in transgenic Drosophila demonstrates RNA-mediated transposition of the LINE I element.The EMBO journal · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cells of the granulocyte-macrophage colony stimulating factor (GM-CSF) or multi-lineage colony stimulating factor (Multi-CSF) dependent line FDC-P1 undergo leukemic transformation after injection into irradiated DBA/2 mice. About one third of factor-independent FDC-P1 variants isolated from leukemic animals express GM-CSF or Multi-CSF, assessed either by bioassay or by sensitive RNA detection using the polymerase chain reaction. All of the GM-CSF-secreting lines studied had a rearrangement in one allele of the GM-CSF gene, three of four Multi-CSF-secreting lines had Multi-CSF gene rearrangements, while factor-independent lines lacking evidence of growth factor production had no demonstrable CSF gene alterations. All rearrangements were characterized by insertions of novel DNA in the 5'-flanking regions of the CSF genes. The inserted segments of DNA varied in size between 0.35 and 6.5 kb and displayed restriction enzyme cleavage maps reminiscent of intracisternal A-particle (IAP) genomes. This was confirmed in two cases by molecular cloning and nucleotide sequence analysis. In these instances, the insertion consisted of solitary IAP long terminal repeats. The transformation system described provides a model for the study of IAP transpositions and their effects on gene activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.