ArticleCell cycle (Georgetown, Tex.)2010
Regulation of ΔNp63α by NFκΒ.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- History-dependent switch-like differentiation of keratinocytes in response to skin barrier damage.PLoS computational biology · 2025Article
- p63-related signaling at a glance.Journal of cell science · 2020Review
- PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis.Carcinogenesis · 2018Article
- Review
- Pathway Regulation of p63, a Director of Epithelial Cell Fate.Frontiers in endocrinology · 2015Review
- Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma.Proteomics · 2015Article
- ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.Translational oncology · 2013Article
- Phospho-ΔNp63α/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure.Cell cycle (Georgetown, Tex.) · 2013Article
- Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63.Journal of skin cancer · 2013Article
- p63 the guardian of human reproduction.Cell cycle (Georgetown, Tex.) · 2012Review
- Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.Cell cycle (Georgetown, Tex.) · 2012Article
- Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.Cell cycle (Georgetown, Tex.) · 2012Article
- Tumor protein p63/nuclear factor κB feedback loop in regulation of cell death.The Journal of biological chemistry · 2011Article
- A symphony of regulations centered on p63 to control development of ectoderm-derived structures.Journal of biomedicine & biotechnology · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
ΔNp63α, the dominant negative isoform of the p63 family is an essential survival factor in head and neck squamous cell carcinoma. This isoform has been shown to be down regulated in response to several DNA damaging agents, thereby enabling an effective cellular response to genotoxic agents. Here, we identify a key molecular mechanism underlying the regulation of ΔNp63α expression in response to extrinsic stimuli, such as chemotherapeutic agents. We show that ΔNp63α interacts with NF-κΒ in presence of cisplatin. We find that NF-κΒ promotes ubiquitin-mediated proteasomal degradation of ΔNp63α. Chemotherapy-induced stimulation of NF-κΒ leads to degradation of ΔNp63α and augments trans-activation of p53 family-induced genes involved in the cellular response to DNA damage. Conversely, inhibition of NF-κΒ with siRNA-mediated silencing NF-κΒ expression attenuates chemotherapy induced degradation of ΔNp63α . These data demonstrate that NF-κΒ plays an essential role in regulating ΔNp63α in response to extrinsic stimuli. Our findings suggest that the activation of NF-κΒ may be a mechanism by which levels of ΔNp63α are reduced, thereby rendering the cells susceptible to cell death in the face of cellular stress or DNA damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.