ArticleCell cycle (Georgetown, Tex.)2010
Transcriptional regulation of HIV-1 gene expression by p53.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The Role of p53 in HIV Infection.Current HIV/AIDS reports · 2023Review
- HIV-1-related factors interact with p53 to influence cellular processes.AIDS research and therapy · 2023Review
- Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner.Viruses · 2023Article
- HIV-1 Transcription Inhibitor 1E7-03 Decreases Nucleophosmin Phosphorylation.Molecular & cellular proteomics : MCP · 2023Article
- HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes.Aging and disease · 2023Article
- The Role of E3 Ligase Pirh2 in Disease.Cells · 2022Review
- Article
- Is lymphopenia different between SARS and COVID-19 patients?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes.Journal of cell communication and signaling · 2019Article
- Tumor suppressor p53 inhibits porcine epidemic diarrhea virus infection via interferon-mediated antiviral immunity.Molecular immunology · 2019Article
- p53 and the Viral Connection: Back into the FutureCancers · 2018Review
- The impact of p53 on the early stage replication of retrovirus.Virology journal · 2017Article
- p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation.Journal of virology · 2015Article
- The p53-microRNA-34a axis regulates cellular entry receptors for tumor-associated human herpes viruses.Medical hypotheses · 2013Article
- Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein.Cell cycle (Georgetown, Tex.) · 2013Article
- Identification and promoter analysis of PERV LTR subtypes in NIH-miniature pig.Molecules and cells · 2013Article
- Role of apoptosis in disease.Aging · 2012Review
- Article
- Cyclin E goes nuts: a cell cycle regulator affects male fertility.Cell cycle (Georgetown, Tex.) · 2010Article
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5 authors at 4 institutions in 1 country.
Funding
Abstract
Several reports have pointed to the negative involvement of p53 in transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat (HIV-1 LTR). However, the mechanisms of this negative effect remain unclear. In here, we showed that over expression of p53 wild type prevented the phosphorylation of serine 2 in the carboxyl terminal domain (CTD) of RNA polymerase II. As a result of this inhibition, p53 stalled transcriptional elongation on the HIV-1 LTR leading to a significant reduction of HIV-1 replication in primary microglia and astrocytes. However, despite the delay/pause caused by p53, viral transcription and replication decreased and then salvaged. These studies suggest that the negative effect of p53 is alleviated by a third factor. In this regard, our Preliminary Data point to the involvement of the Pirh2 protein in p53 inhibition. Therefore, we suggest that p53 may be a novel therapeutic target for the inhibition of HIV-1 gene expression and replication and the treatment of AIDS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.