Evidence map›Paper›PMID 21088285›Full record

ArticleCirculation research2010

Myocyte turnover in the aging human heart.

Jan Kajstura, Narasimman Gurusamy, Barbara Ogórek, Polina Goichberg, Carlos Clavo-Rondon, Toru Hosoda, Domenico D'Amario, Silvana Bardelli, Antonio P Beltrami, Daniela Cesselli and 8 more

RetractedOpen access · greenAbstract readComparative StudyRetracted Publication
PubMed Publisher
In one paragraph

Article in Circulation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
35.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 286 citations in OpenAlex.

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  12. Sex differences and the left ventricle: morphology matters.European heart journal. Cardiovascular Imaging · 2020
    Article
  13. Sex and Gender Differences in Heart Failure.International journal of heart failure · 2020
    Review
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  17. Senescent cells: a therapeutic target for cardiovascular disease.The Journal of clinical investigation · 2018
    Review
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Jan KajsturaDepartment of Anesthesia and Medicine and Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. jkajstura@partners.org
Narasimman Gurusamy
Barbara Ogórek
Polina Goichberg
Carlos Clavo-Rondon
Toru Hosoda
Domenico D'Amario
Silvana Bardelli
Antonio P Beltrami
Daniela Cesselli
Rossana Bussani
Federica del Monte
Federico Quaini
Marcello Rota
Carlo A Beltrami
Bruce A Buchholz
Annarosa Leri
Piero Anversa
University of Trieste · IT

Funding

Stem Cells in the Developing HeartR01HL091021 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROTA, MARCELLO · 2009 to 2013
$2.4M
NHLBI NIH HHS R01 HL091021PHS HHS NCRR13641
6 · The paper itself

Abstract

rationaleThe turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology.

objectiveThe effects of age and gender on the magnitude of myocyte regeneration and the origin of newly formed cardiomyocytes were determined. METHODS AND

resultsThe interaction of myocyte replacement, cellular senescence, growth inhibition, and apoptosis was measured in normal female (n=32) and male (n=42) human hearts collected from patients 19 to 104 years of age who died from causes other than cardiovascular diseases. A progressive loss of telomeric DNA in human cardiac stem cells (hCSCs) occurs with aging and the newly formed cardiomyocytes inherit short telomeres and rapidly reach the senescent phenotype. Our data provide novel information on the superior ability of the female heart to sustain the multiple variables associated with the development of the senescent myopathy. At all ages, the female heart is equipped with a larger pool of functionally competent hCSCs and younger myocytes than the male myocardium. The replicative potential is higher and telomeres are longer in female hCSCs than in male hCSCs. In the female heart, myocyte turnover occurs at a rate of 10%, 14%, and 40% per year at 20, 60, and 100 years of age, respectively. Corresponding values in the male heart are 7%, 12%, and 32% per year, documenting that cardiomyogenesis involves a large and progressively increasing number of parenchymal cells with aging. From 20 to 100 years of age, the myocyte compartment is replaced 15 times in women and 11 times in men.

conclusionsThe human heart is a highly dynamic organ regulated by a pool of resident hCSCs that modulate cardiac homeostasis and condition organ aging.

Indexed as

AdultAdult Stem CellsAgedAged, 80 and overApoptosisCell DeathCell DifferentiationCells, CulturedCellular SenescenceFemaleHeartHumansMaleMiddle AgedMyocytes, CardiacSex Characteristics

Identifiers

PMID21088285
OpenAlexW2169908939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.