ArticleArteriosclerosis, thrombosis, and vascular biology2011
Vascular smooth muscle cell peroxisome proliferator-activated receptor-γ mediates pioglitazone-reduced vascular lesion formation.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Anti-inflammatory mechanisms of the vascular smooth muscle PPARγ.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2021Review
- Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.Journal of diabetes research · 2020 · on this mapReview
- Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes.Frontiers in physiology · 2018Review
- Autologous fat transplants to deliver glitazone and adiponectin for vasculoprotection.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways.Scientific reports · 2016Article
- PPARγ Regulation in Hypertension and Metabolic Syndrome.Current hypertension reports · 2015Review
- 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model.BioMed research international · 2015Article
- Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes.Cell metabolism · 2014Review
- Evolving concepts and treatment strategies for cardiac allograft vasculopathy.Current treatment options in cardiovascular medicine · 2014Article
- Endothelial dysfunction and cardiac allograft vasculopathy.Journal of cardiovascular translational research · 2013Review
- Disruption of endothelial peroxisome proliferator-activated receptor γ accelerates diet-induced atherogenesis in LDL receptor-null mice.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Molecular targets related to inflammation and insulin resistance and potential interventions.Journal of biomedicine & biotechnology · 2012Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivePeroxisome proliferator-activated receptor-γ (PPARγ) has been reported to decrease vascular lesion formation. However, the critical role of vascular smooth muscle cell (VSMC) PPARγ in vascular lesion formation following transplantation is not well understood. In this study, we investigated the role of VSMC PPARγ-mediated signaling in transplantation-associated vascular lesion formation. METHODS AND
resultsCarotid arteries from smooth muscle cell-selective PPARγ knockout (SMPG KO) and wild-type mice were transplanted to CBA/CaJ recipient mice. The recipient mice received a control diet or pioglitazone-containing diet. Pioglitazone reduced vascular lesion formation in transplanted wild-type, but not in SMPG KO carotid arteries. Histological analysis suggested that PPARγ attenuates vascular lesion formation through antiinflammatory signaling, as evidenced by the increase of intimal inflammatory cells and tumor necrosis factor-α expression in SMPG KO allografts. Intravital microscopy revealed increased inflammatory cell rolling and attachment to endothelial cells in small blood vessels of SMPG KO mice following cytokine stimulation. SMPG KO mice, as shown by Western blotting, have elevated vascular cell adhesion molecule-1 (VCAM-1) expression. Furthermore, immunohistochemistry demonstrated SMPG KO allografts have increased VCAM-1.
conclusionsLoss of PPARγ in VSMC promotes transplantation-associated vascular lesion formation through increased VCAM-1 expression. VSMC PPARγ also mediates pioglitazone-reduced vascular lesion formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.