ArticleStroke2011
Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats.
Article in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 106 citations in OpenAlex.
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery.Neuroscience insights · 2026Article
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- Anti-Nogo-A antibody treatment six months post-stroke results in neuroplasticity and improved functional outcome.Experimental neurology · 2025Article
- Article
- Anti-Nogo-A Antibody Therapy Improves Functional Outcome Following Traumatic Brain Injury.Neurorehabilitation and neural repair · 2023Article
- The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia.Cells · 2023Article
- The factors affecting neurogenesis after stroke and the role of acupuncture.Frontiers in neurology · 2023Review
- Anti-NOGO Antibody Neuroprotection in a Rat Model of NAION.Translational vision science & technology · 2021Article
- NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates.Nature communications · 2021Article
- Motor tract reorganization after acute central nervous system injury: a translational perspective.Neural regeneration research · 2021Review
- Axonal remodeling of the corticospinal tract during neurological recovery after stroke.Neural regeneration research · 2021Review
- Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke.Frontiers in neurology · 2021Article
- Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injury.Cell death & disease · 2020Article
- Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries.Neural development · 2020Review
- Constraint-induced movement therapy enhances angiogenesis and neurogenesis after cerebral ischemia/reperfusion.Neural regeneration research · 2019Article
- Early constraint-induced movement therapy affects behavior and neuronal plasticity in ischemia-injured rat brains.Neural regeneration research · 2019Article
- Therapeutic exercise accompanied by neuronal modulation to enhance neurotrophic factors in the brain with central nervous system disorders.Physical therapy research · 2019Review
- Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposewe have shown that anti-Nogo-A immunotherapy to neutralize the neurite growth inhibitory protein Nogo-A results in functional improvement and enhanced plasticity after ischemic stroke in the adult rat. The present study investigated whether functional improvement and neuronal plasticity can be induced by this immunotherapy when administered to the chronic stroke-impaired rat.
methodsadult rats were trained to perform the skilled forelimb reaching test, followed by permanent middle cerebral artery occlusion to impair the preferred forelimb. Nine weeks after stroke, animals showing a profound deficit were randomly distributed to 3 groups: no treatment, control antibody, or anti-Nogo-A antibody (11C7). Animals were tested weekly after stroke surgery and daily after antibody treatment until the end of the study. Biotin dextran amine tracing was injected into the nonlesioned forelimb motor cortex at the end of behavioral testing to determine axonal plasticity.
resultsall rats showed similar forelimb impairment before treatment. Animals treated with anti-Nogo-A immunotherapy started to show improvement 3 weeks after treatment. Such improvement became significantly better than stroke-only control and control Ab-treated animals, and persisted to the end of the study. Biotin dextran amine-labeled axonal fiber analysis also showed significant enhanced corticorubral axonal sprouting from the contralesional forelimb motor cortex to the deafferented red nucleus in the anti-Nogo-A immunotherapy rats.
conclusionsthese results indicate that improvement of chronic neurological deficits and enhancement of neuronal plasticity can be induced in the adult rat with anti-Nogo-A immunotherapy, and that this therapy may be used to restore function even when administered long after ischemic brain damage has occurred.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.