Evidence map›Paper›PMID 21087941›Full record

Trial reportAJNR. American journal of neuroradiology2011

MR imaging of partially thrombosed cerebral aneurysms: characteristics and evolution.

A J Martin, S W Hetts, W P Dillon, R T Higashida, V Halbach, C F Dowd, M T Lawton, D Saloner

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Obstructive hydrocephalus due to high-volume liquid embolic agent embolization for management of pediatric arteriovenous malformations: illustrative case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Advanced cross-sectional imaging of cerebral aneurysms.The British journal of radiology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. High-resolution intracranial vessel wall imaging: imaging beyond the lumen.Journal of neurology, neurosurgery, and psychiatry · 2016
    Review
  20. Giant Intracranial Aneurysms at 7T MRI.AJNR. American journal of neuroradiology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

A J MartinDepartment of Radiology, University of California, San Francisco, 94143, USA. Alastair.Martin@radiology.ucsf.edu
S W Hetts
W P Dillon
R T Higashida
V Halbach
C F Dowd
M T Lawton
D Saloner
University of California, San Francisco · USAmerican Society of Neuroradiology · US

Funding

Endovascular Magnetic Catheter for Interventional MRIR01EB012031 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM, MARTIN, ALASTAIR J · 2011 to 2021
$4.8M
Determinants of Intracranial Aneurysm GrowthR01NS059944 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALONER, DAVID A · 2009 to 2013
$1.7M
NIBIB NIH HHS R01 EB012031NINDS NIH HHS R01 NS059944
6 · The paper itself

Abstract

background and purposeA comprehensive evaluation of aneurysmal morphometry requires appreciation of both the vascular lumen and the intraluminal thrombus. MR imaging methods can both evaluate the lumen and directly image the vessel wall. We investigated the ability of T1-weighted, T2-weighted, and steady-state MR imaging techniques to delineate thrombus morphology and reveal changes with time. MATERIALS AND

methodsNine patients with fusiform basilar or intracranial vertebral artery aneurysms that contained intraluminal thrombus were studied with MR imaging. All patients underwent at least 2 imaging sessions, which were separated by 4-22 months. Analysis of signal intensity to determine the mean signal intensity from thrombus, blood, CSF, and brain in matched regions was performed. Aneurysm maximal diameter and cross-sectional area were determined with and without thrombus.

resultsThrombus was identified on all image sequences, and its general appearance was consistent between imaging sessions. Thrombus produced the highest and most consistent signal intensities with T1-weighted and steady-state techniques, though the latter showed superior contrast between luminal blood and thrombus. Heterogeneity within clot was evident in 4/9 of patients, with peripheral hyperintensity being a common feature.

conclusionsSteady-state imaging was found to be superior to T1- and T2-weighted imaging for delineating and characterizing intraluminal thrombus within aneurysms. The imaging characteristics of intraluminal thrombus proved to be very consistent for long periods. Assessment of overall aneurysm size, including thrombosed portions, permits more accurate evaluation of aneurysm growth and concomitantly may permit more informed clinical decision-making with regard to the timing and need for aneurysm treatment.

Indexed as

AdultAgedCohort StudiesContrast MediaDisease ProgressionFemaleHumansIntracranial AneurysmIntracranial ThrombosisMagnetic Resonance AngiographyMaleMiddle AgedVertebrobasilar InsufficiencyContrast Media

Identifiers

PMID21087941
PMCPMC3542832
OpenAlexW2106301934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.