ArticleArthritis research & therapy2010
Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study.
Article in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Association of the IRF5 rs2004640 polymorphism with rheumatoid arthritis: a meta-analysis.Rheumatology international · 2013Pooled it
- The glutathione S-transferase M1 and P1 polymorphisms and rheumatoid arthritis: a meta-analysis.Molecular biology reports · 2012Pooled it
- Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis.Arthritis care & research · 2026Article
- Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease.Seminars in arthritis and rheumatism · 2022Article
- Elevations in adipocytokines and mortality in rheumatoid arthritis.Rheumatology (Oxford, England) · 2022Article
- Adipocytokines and achievement of low disease activity in rheumatoid arthritis.Seminars in arthritis and rheumatism · 2022Article
- Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis.Annals of the rheumatic diseases · 2021Article
- Association of Agricultural, Occupational, and Military Inhalants With Autoantibodies and Disease Features in US Veterans With Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice.Scientific reports · 2020Article
- Exposure to ambient air pollution and autoantibody status in rheumatoid arthritis.Clinical rheumatology · 2020Article
- HLA-DRB1 Haplotypes, Shared Epitope, and Disease Outcomes in US Veterans with Rheumatoid Arthritis.The Journal of rheumatology · 2019Observational
- Obesity, Weight Loss, and Progression of Disability in Rheumatoid Arthritis.Arthritis care & research · 2018Article
- Chronic lung disease in U.S. Veterans with rheumatoid arthritis and the impact on survival.Clinical rheumatology · 2018Observational
- Measurement of absolute copy number variation of Glutathione S-Transferase M1 gene by digital droplet PCR and association analysis in Tunisian Rheumatoid Arthritis population.Journal of clinical laboratory analysis · 2018Article
- Utilization of Care Outside the Veterans Affairs Health Care System by US Veterans With Rheumatoid Arthritis.Arthritis care & research · 2017Observational
- Redox homeostasis, T cells and kidney diseases: three faces in the dark.Clinical kidney journal · 2016Article
- Weight Loss, the Obesity Paradox, and the Risk of Death in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Predictors of longterm changes in body mass index in rheumatoid arthritis.The Journal of rheumatology · 2015Article
- Insights and Implications of the VA Rheumatoid Arthritis Registry.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2015Review
- Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case-control study.Arthritis research & therapy · 2014Article
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Authors and funding
20 authors at 11 institutions in 1 country.
Funding
Abstract
introductionA deletion polymorphism in glutathione S-transferase Mu-1 (GSTM1-null) has previously been implicated to play a role in rheumatoid arthritis (RA) risk and progression, although no prior investigations have examined its associations with anticitrullinated protein antibody (ACPA) positivity. The purpose of this study was to examine the associations of GSTM1-null with ACPA positivity in RA and to assess for evidence of interaction between GSTM1 and HLA-DRB1 shared epitope (SE).
methodsAssociations of GSTM1-null with ACPA positivity were examined separately in two RA cohorts, the Veterans Affairs Rheumatoid Arthritis (VARA) registry (n = 703) and the Study of New-Onset RA (SONORA; n = 610). Interactions were examined by calculating an attributable proportion (AP) due to interaction.
resultsA majority of patients in the VARA registry (76%) and SONORA (69%) were positive for ACPA with a similar frequency of GSTM1-null (53% and 52%, respectively) and HLA-DRB1 SE positivity (76% and 71%, respectively). The parameter of patients who had ever smoked was more common in the VARA registry (80%) than in SONORA (65%). GSTM1-null was significantly associated with ACPA positivity in the VARA registry (odds ratio (OR), 1.45; 95% confidence interval (CI), 1.02 to 2.05), but not in SONORA (OR, 1.00; 95% CI, 0.71 to 1.42). There were significant additive interactions between GSTM1 and HLA-DRB1 SE in the VARA registry (AP, 0.49; 95% CI, 0.21 to 0.77; P < 0.001) in ACPA positivity, an interaction replicated in SONORA (AP, 0.38; 95% CI, 0.00 to 0.76; P = 0.050).
conclusionsThis study is the first to show that the GSTM1-null genotype, a common genetic variant, exerts significant additive interaction with HLA-DRB1 SE on the risk of ACPA positivity in RA. Since GSTM1 has known antioxidant functions, these data suggest that oxidative stress may be important in the development of RA-specific autoimmunity in genetically susceptible individuals.
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