ArticleInternational journal of radiation biology2011
Germline minisatellite mutations in survivors of childhood and young adult cancer treated with radiation.
Article in International journal of radiation biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- A Critical Review of the Removal of Radionuclides from Wastewater Employing Activated Carbon as an Adsorbent.Materials (Basel, Switzerland) · 2022Review
- The Likelihood of Adverse Pregnancy Outcomes and Genetic Disease (Transgenerational Effects) from Exposure to Radioactive Fallout from the 1945 Trinity Atomic Bomb Test.Health physics · 2020Article
- Mutation Induction in Humans and Mice: Where Are We Now?Cancers · 2019Review
- Cryptorchidism after the Fukushima Daiichi Nuclear Power Plant accident:causation or coincidence?Fukushima journal of medical science · 2019Review
- Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Obstetric and offspring risks of women's morbid conditions linked to prior anticancer treatments.Reproductive biology and endocrinology : RB&E · 2016Review
- Very low-level heteroplasmy mtDNA variations are inherited in humans.Journal of genetics and genomics = Yi chuan xue bao · 2013Article
- The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation.Mutation research · 2012Article
- Congenital anomalies in the children of cancer survivors: a report from the childhood cancer survivor study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Genetic disease in the children of Danish survivors of childhood and adolescent cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents.Mutation researchReview
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
purposeTo investigate minisatellite germline mutation rates in survivors of childhood and young adult cancer who received radiotherapy. MATERIALS AND
methodsDNA samples from 100 families, where one parent was a cancer survivor, were analysed for mutations at eight hypervariable minisatellite loci (B6.7, CEB1, CEB15, CEB25, CEB36, MS1, MS31, MS32) by Southern hybridisation.
resultsNo significant difference was observed between the paternal mutation rate of 5.6% in exposed fathers with a mean preconceptional testicular dose of 1.23 Gy (56 mutations in 998 informative alleles) and that of 5.8% in unexposed fathers (17 in 295 informative alleles). Subgrouping the exposed fathers into dose groups of < 0.10 Gy, 0.10-0.99 Gy, 1.00-1.99 Gy, ≥ 2.00 Gy revealed no significant differences in paternal mutation rate in comparison with the unexposed fathers. Maternal mutation rates of 1.6% in cancer survivor mothers with a mean preconceptional ovarian dose of 0.58 Gy (five mutations in 304 informative alleles) and 2.1% in unexposed mothers (21 in 987 informative alleles) were not significantly different. There were no differences in minisatellite mutation rates associated with treatment with chemotherapeutic agents.
conclusionsThis study provides evidence that preconception radiotherapy for childhood or early adulthood cancer does not increase the germline minisatellite mutation rate.
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