ArticleMolecular biology reports2011
The CSN1S1 N and F alleles identified by PCR-SSCP and their associations with milk yield and composition in Chinese dairy goats.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 16 citations in OpenAlex.
- Investigation of a RareAnimals : an open access journal from MDPI · 2026Article
- A New AS-PCR Method to DetectAnimals : an open access journal from MDPI · 2023Article
- An 11-bp Indel Polymorphism within theAnimals : an open access journal from MDPI · 2019Article
- Differential Expression of the Alpha S1 Casein and Beta-Lactoglobulin Genes in Different Physiological Stages of the Adani Goats Mammary Glands.Iranian journal of biotechnology · 2016Article
- Effects of CSN1S2 Genotypes on Economic Traits in Chinese Dairy Goats.Asian-Australasian journal of animal sciences · 2013Article
- Identification of an intronic regulatory mutation at the buffalo αS1-casein gene that triggers the skipping of exon 6.Molecular biology reports · 2013Article
- Association of polymorphism of the β(1, 4)-galactosyltransferase-I gene with milk production traits in Holsteins.Molecular biology reports · 2012Article
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11 authors at 1 institution in 1 country.
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Abstract
A method was depicted to identify null allele CSN1S1 N and low allele CSN1S1 F of the CSN1S1 gene of goat using PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism). First, primer A was designed to amplify the exon 9 of CSN1S1 gene which produced three genotypes AA, AB, and BB. Among these three genotypes, only AA and AB individuals had a cytosine deletion at exon 9 after DNA sequencing, which cannot be used to identify the N and F alleles. Therefore, primer B was used to amplify intron 14 of CSN1S1 of described AA and AB individuals. Genotypes FF, FN and NN were detected within AA individuals and genotypes FO and NO were detected in the above AB individuals. The frequencies of F and N alleles in 708 samples from Xinong Saanen (XS) and Guanzhong (GZ) dairy goat breeds were 0.1139, 0.0927, and 0.2376, 0.1193, respectively. In 268 XS samples, the individuals with NN genotype contained a significant lower protein content than that of other genotypes (P<0.01). Individuals of FF genotype had significant higher milk yield than that of NO genotype in the first milk lactation of 202 XS individuals (P<0.05). Therefore, the variability at CSN1S1 locus contains enough genetic diversity to be potentially useful in improving the quality and production of milk in Chinese dairy goat breeds.
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