ArticleDevelopment genes and evolution2010
Rapid evolution of a novel signalling mechanism by concerted duplication and divergence of a BMP ligand and its extracellular modulators.
Article in Development genes and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Shrew is an essential, recently evolved, Drosophila specific gene required for formation of the embryonic BMP activity gradient.Developmental biology · 2026Article
- Review
- Article
- The dorsoventral patterning ofEvoDevo · 2018Article
- Non-canonical dorsoventral patterning in the moth midgeEvoDevo · 2017Article
- Molecular characterization of the BMP7 gene and its potential role in shell formation in Pinctada martensii.International journal of molecular sciences · 2014Article
- Strategies for exploring TGF-β signaling in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Article
- Evolution and expression of BMP genes in flies.Development genes and evolution · 2013Article
- Fine-tuned shuttles for bone morphogenetic proteins.Current opinion in genetics & development · 2013Review
- Comparative transcriptomics of early dipteran development.BMC genomics · 2013Article
- BMP7 can promote osteogenic differentiation of human periosteal cells in vitro.Molecular biology reports · 2012Article
- Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster.The Journal of biological chemistry · 2012Article
- Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- BMP signaling components in embryonic transcriptomes of the hover fly Episyrphus balteatus (Syrphidae).BMC genomics · 2011Article
- Decapentaplegic (dpp) regulates the growth of a morphological novelty, beetle horns.Development genes and evolution · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
Gene duplication and divergence is widely considered to be a fundamental mechanism for generating evolutionary novelties. The Bone Morphogenetic Proteins (BMPs) are a diverse family of signalling molecules found in all metazoan genomes that have evolved by duplication and divergence from a small number of ancestral types. In the fruit fly Drosophila, there are three BMPs: Decapentaplegic (Dpp) and Glass bottom boat (Gbb), which are the orthologues of vertebrate BMP2/4 and BMP5/6/7/8, respectively, and Screw (Scw), which, at the sequence level, is equally divergent from Dpp and Gbb. It has recently been shown that Scw has arisen from a duplication of Gbb in the lineage leading to higher Diptera. We show that since this duplication event, Gbb has maintained the ancestral BMP5/6/7/8 functionality while Scw has rapidly diverged. The evolution of Scw was accompanied by duplication and divergence of a suite of extracellular regulators that continue to diverge together in the higher Diptera. In addition, Scw has become restricted in its receptor specificity: Gbb proteins can signal through the Type I receptors Thick veins (Tkv) and Saxophone (Sax), while Scw signals through Sax. Thus, in a relatively short span of evolutionary time, the duplication event that gave rise to Scw produced not only a novel ligand but also a novel signalling mode that is functionally distinct from the ancestral Gbb mode. Our results demonstrate the plasticity of the BMP pathway not only in evolving new family members and new functions but also new signalling modes by redeploying key regulators in the pathway.
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