ArticlePsychopharmacology2011
A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Effect of cholinergic neurotransmission modulation on visual spatial paired associate learning in healthy human adults.Psychopharmacology · 2013Trial
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- Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer.Cell reports. Medicine · 2024Article
- Automating licking bias correction in a two-choice delayed match-to-sample task to accelerate learning.Scientific reports · 2023Article
- Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes.Scientific data · 2023Article
- Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats.eNeuro · 2023Article
- Use of an Automated Mouse Touchscreen Platform for Quantification of Cognitive Deficits After Central Nervous System Injury.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys.Biological psychiatry global open science · 2023Article
- Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson's disease Lrrk2Experimental neurology · 2022Article
- Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice.Brain research bulletin · 2022Article
- Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats.Neurobiology of aging · 2022Article
- Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus).Scientific reports · 2021Article
- Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.ACS pharmacology & translational science · 2020Review
- Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task.Scientific reports · 2020Article
- Article
- Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice.Psychopharmacology · 2018Article
- Assessment of Cognitive Impairment in a Mouse Model of High-Fat Diet-Induced Metabolic Stress with Touchscreen-Based Automated Battery System.Experimental neurobiology · 2018Article
- Evaluation of Touchscreen Chambers To Assess Cognition in Adult Mice: Effect of Training and Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer's Disease and Dementia.Journal of molecular neuroscience : MN · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationalePerformance on the Cambridge Neuropsychological Test Automated Battery touchscreen paired-associates learning (PAL) test is predictive of Alzheimer's disease and impaired in schizophrenia and chronic drug users. An automated computer touchscreen PAL task for rats has been previously established. A pharmacologically validated PAL task for mice would be a highly valuable tool, which could be useful for a number of experimental aims including drug discovery.
objectivesThis study sought to investigate the effects of systemic administration of cholinergic agents on task performance in C57Bl/6 mice.
methodsScopolamine hydrobromide (0.02, 0.2, and 2.0 mg/kg), dicyclomine hydrochloride (M(1) receptor antagonist; 2.0, 4.0, and 8.0 mg/kg), and donepezil hydrochloride (cholinesterase inhibitor; 0.03, 0.1, and 0.3 mg/kg) were administered post-acquisition in C57Bl/6 mice performing the PAL task.
resultsScopolamine (0.2 and 2.0 mg/kg) and dicyclomine (at all administered doses) significantly impaired PAL performance. A significant facilitation in PAL was revealed in mice following donepezil administration (0.3 mg/kg).
conclusionsThe present study shows that mice can acquire the rodent PAL task and that the cholinergic system is important for PAL task performance. M(1) receptors in particular are likely implicated in normal performance of PAL. The finding that mouse PAL can detect both impairments and improvements indicates that this task could prove to be a highly valuable tool for a number of experimental aims including drug discovery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.