ArticleJournal of molecular neuroscience : MN2011
Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice.
Article in Journal of molecular neuroscience : MN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Leptin: role over central nervous system in epilepsy.BMC neuroscience · 2018Pooled it
- Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice.Molecular neurobiology · 2024Article
- Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice.Nature communications · 2022Article
- Hypothalamic Astrocytes as a Specialized and Responsive Cell Population in Obesity.International journal of molecular sciences · 2021Review
- Altered Brain Leptin and Leptin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain.Frontiers in neuroscience · 2020Article
- Leptin-Mediated Sympathoexcitation in Obese Rats: Role for Neuron-Astrocyte Crosstalk in the Arcuate Nucleus.Frontiers in neuroscience · 2019Article
- The Effects of Leptin on Glial Cells in Neurological Diseases.Frontiers in neuroscience · 2019Review
- Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus.Molecular neurobiology · 2018Article
- Review
- Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface-the protective role for BDNF.Journal of neuroinflammation · 2018Article
- Differential hypothalamic leptin sensitivity in obese rat offspring exposed to maternal and postnatal intake of chocolate and soft drink.Nutrition & diabetes · 2017Article
- Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.Frontiers in endocrinology · 2017Review
- Peptides and the blood-brain barrier.Peptides · 2015Review
- Role of Astrocytes in Leptin Signaling.Journal of molecular neuroscience : MN · 2015Article
- Role of non-neuronal cells in body weight and appetite control.Frontiers in endocrinology · 2015Review
- Leptin: a biomarker for sleep disorders?Sleep medicine reviews · 2014Article
- Estrogen, astrocytes and the neuroendocrine control of metabolism.Reviews in endocrine & metabolic disorders · 2013Review
- Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.Journal of molecular neuroscience : MN · 2013Article
- Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.Brain, behavior, and immunity · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We tested the hypothesis that astrocytic activity modulates neuronal uptake and signaling of leptin in the adult-onset obese agouti viable yellow (A vy) mouse. In the immunohistochemical study, A vy mice were pretreated with the astrocyte metabolic inhibitor fluorocitrate or phosphate-buffered saline (PBS) vehicle intracerebroventricularly (icv) followed 1 h later by Alexa568-leptin. Confocal microscopy showed that fluorocitrate pretreatment reduced astrocytic uptake of Alexa568-leptin 30 min after icv while increasing neuronal uptake in the arcuate nucleus and dorsomedial hypothalamus. Fluorocitrate also induced mild astrogliosis and moderately increased pSTAT3 immunopositive neurons in response to Alexa568-leptin in the dorsomedial hypothalamus. In the Western blotting study, A vy mice were pretreated with either PBS or fluorocitrate, and received PBS or leptin 1 h later followed by determination of pSTAT3 and GFAP expression an additional 30 min afterward. The results show that fluorocitrate induced a mild pSTAT3 activation but attenuated leptin-induced pSTAT3 activation and decreased GFAP expression independently of leptin treatment. We conclude that inhibition of astrocytic activity resulted in enhanced neuronal leptin uptake and signaling. This suggests opposite roles of astrocytes and neurons in leptin's actions in the A vy mouse with adult-onset obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.