Evidence map›Paper›PMID 21086047›Full record

ArticleJournal of inherited metabolic disease2010

Advances and challenges in phenylketonuria.

Cary O Harding, Nenad Blau

Abstract readEditorial
PubMed Publisher
In one paragraph

Article in Journal of inherited metabolic disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. An ADAR2-mimic base editor for efficient C-to-U RNA editing in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. The status ofMedical journal of the Islamic Republic of Iran · 2019
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Cary O Harding
Nenad Blau
Oregon Health & Science University · USSwiss Integrative Center for Human Health · CH

Funding

Augmented Phenylalanine Clearance by Muscles as Novel Therapy for PhenylketonuriaR01HD057033 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARDING, CARY O. · 2009 to 2013
$1.6M
Metabolic Engineering as Therapy for Murine PKUR01DK059371 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARDING, CARY O. · 2001 to 2009
$1.4M
NICHD NIH HHS HD057033NIDDK NIH HHS DK059371
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBiopterinsEnzyme Replacement TherapyGenetic TherapyHumansInfant, NewbornMiceMice, TransgenicNeonatal ScreeningPhenylalanine HydroxylasePhenylketonuriasTherapeuticsBiopterinsPhenylalanine Hydroxylasesapropterin

Identifiers

PMID21086047
OpenAlexW1988989714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.