ArticleJournal of assisted reproduction and genetics2011
Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population.
Article in Journal of assisted reproduction and genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Exploring Progesterone Deficiency in First-Trimester Miscarriage and the Impact of Hormone Therapy on Foetal Development: A Scoping Review.Children (Basel, Switzerland) · 2024Article
- Luteal phase support in assisted reproductive technology.Nature reviews. Endocrinology · 2024Review
- Review
- What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review.International journal of molecular sciences · 2021Review
- Evaluation of Expression and Phosphorylation of Progesterone Receptor in Endometrial Stromal Cells of Patients with Recurrent Implantation Failure Compared to Healthy Fertile Women.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Genetic variations in estrogen and progesterone pathway genes in preeclampsia patients and controls in Bavaria.Archives of gynecology and obstetrics · 2021Article
- Gene expression analysis of membrane progesterone receptors in women with recurrent spontaneous abortion: a case control study.BMC research notes · 2019Article
- Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province.Journal of genetics · 2016Article
- Association of the Alu insertion polymorphism in the progesterone receptor gene with breast cancer in a Mexican population.Archives of medical science : AMS · 2015Article
- Association of progesterone receptor gene polymorphism with male infertility and clinical outcome of ICSI.Journal of assisted reproduction and genetics · 2013Article
- Association of progesterone receptor gene (PGR) variants and breast cancer risk in African American women.Breast cancer research and treatment · 2013Article
- Effects of PGR and ESRα genotypes on the pregnancy rates after embryo transfer in Luxi cattle.Molecular biology reports · 2013Article
- Progesterone and autoimmune disease.Autoimmunity reviews · 2012Review
- Role of nuclear progesterone receptor isoforms in uterine pathophysiology.Human reproduction updateReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL.
methodsOne hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped.
resultsWe found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values = 0.006). In addition, the C-C haplotype, which consists of rs590688C > G and rs11224592T > C, is associated with a decreased risk of RPL (p = 0.004).
conclusionPROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
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