ArticleVirchows Archiv : an international journal of pathology2011
Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas.
Article in Virchows Archiv : an international journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Prognostic Significance of P16BioMed research international · 2018Pooled it
- Predicting inguinal lymph node metastasis in penile squamous cell carcinoma, from imaging, molecular biomarkers to multimodal AI: a narrative review.Translational andrology and urology · 2026Review
- Molecular Subtypes of Vulvar Squamous Cell Carcinoma: The Significance of HPV-Independent/p53 Wild Type.Cancers · 2024Review
- Human Papillomavirus Infection in Penile Cancer: Multidimensional Mechanisms and Vaccine Strategies.International journal of molecular sciences · 2023Review
- Prognostic Markers and Trials in Penile Cancer.Urology research & practice · 2023Article
- HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics.Clinical epigenetics · 2022Article
- Primary adenosquamous carcinoma of the endometrium with glassy cell features. A diagnostic pitfall as a very rare tumour type in the endometrium.Pathologica · 2022Article
- Proteases and HPV-Induced Carcinogenesis.Cancers · 2022Review
- HPV E6/E7 mRNA in situ hybridization in endocervical adenocarcinoma: implications for prognosis and diagnosis.Cancer cell international · 2021Article
- [Conventional grading vs. molecular grading : Decision aids for clinical routine].Der Urologe. Ausg. A · 2021Review
- Penile cancer: potential target for immunotherapy?World journal of urology · 2021Review
- P16 and HPV Genotype Significance in HPV-Associated Cervical Cancer-A Large Cohort of Two Tertiary Referral Centers.International journal of molecular sciences · 2021Article
- Evaluation of human papillomavirus (HPV) prediction using the International Endocervical Adenocarcinoma Criteria and Classification system, compared to p16 immunohistochemistry and HPV RNA in-situ hybridization.Journal of pathology and translational medicine · 2020Article
- Understanding genomics and the immune environment of penile cancer to improve therapy.Nature reviews. Urology · 2020Review
- [Penile cancer : Diagnosis and treatment].Der Urologe. Ausg. A · 2020Article
- Prognostic implications of genotyping and p16 immunostaining in HPV-positive tumors of the uterine cervix.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- The molecular pathogenesis of penile carcinoma-current developments and understanding.Virchows Archiv : an international journal of pathology · 2019Review
- [Molecular tumor board penile cancer-a challenge].Der Urologe. Ausg. A · 2019Review
- High TRIAP1 expression in penile carcinoma is associated with high risk of recurrence and poor survival.Annals of translational medicine · 2019Article
- International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.The American journal of surgical pathology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in the p16/cyclinD1/Rb and ARF/Mdm2/p53 pathways are frequent events in the pathogenesis of squamous cell carcinomas. Different mechanisms of p16 regulation have been described for penile carcinomas so far. Therefore, expression of p16 and p53 was immunohistochemically detected with monoclonal antibodies in 52 primary invasive penile squamous cell carcinomas. The carcinomas were analyzed for allelic loss (LOH) in p16(INK4A) and p53, as well as for mutations in the p16(INK4A) and the p53 gene. In addition, we examined the promoter status of p16(INK4A) by methylation-specific PCR. The presence of human papilloma virus (HPV) 6/11, HPV 16 and HPV 18 DNA was analyzed by PCR. Data were compared to clinical data. Concerning p16, 26 (50%) tumors showed positive immunohistochemistry, 32 (62%) tumors showed allelic loss and 22 tumors (42%) showed promoter hypermethylation. All tumors with negative p16 immunohistochemistry showed LOH near the p16(INK4A) locus and/or hypermethylation of the p16(INK4A) promoter. HPV 16 DNA was detected in 17 tumors, ten of them with positive p16 immunostaining. The remaining seven tumors with negative p16 staining showed allelic loss and/or promoter hypermethylation. Evidence of lymph node metastasis was significantly associated with negative p16 immunohistochemistry as well as with combined LOH and promoter hypermethylation (p = 0.003 and p = 0.018, respectively). Allelic loss around p53 was found in 22 tumors (42%), and seven mutations of the p53 gene could be demonstrated in our tumors. No correlations could be found between any p53 alteration and clinical parameters.
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