ArticleRheumatology international2012
Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Rheumatic associations of autoimmune thyroid disease: a systematic review.Clinical rheumatology · 2019Pooled it
- Central Sensitization in Spondyloarthritis: Implications for Personalized Medicine.Journal of personalized medicine · 2026Article
- The Role of Central Sensitization in Autoimmune Connective Tissue Diseases: A Comparative Cross-Sectional Study.International journal of rheumatic diseases · 2025Article
- Effect of Steroids on Patients With Fibromyalgia/Chromic Widespread Pain: An Observational Study.Cureus · 2024Article
- The relationship between migraine and Hashimoto's thyroiditis: a single center experience.Frontiers in neurology · 2024Article
- Hashimoto's thyroiditis and coexisting disorders in correlation with HLA status-an overview.Wiener medizinische Wochenschrift (1946) · 2023Review
- A retrospective analysis of the prevalence and impact of associated comorbidities on fibromyalgia outcomes in a tertiary care center.Frontiers in medicine · 2023Article
- Review
- Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update.International journal of molecular sciences · 2021Review
- Persisting symptoms in patients with Hashimoto's disease despite normal thyroid hormone levels: Does thyroid autoimmunity play a role? A systematic review.Journal of translational autoimmunity · 2021Review
- Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies.Frontiers in medicine · 2020Article
- Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model.Frontiers in immunology · 2018Review
- A narrative review on the difficulties associated with fibromyalgia diagnosis.Therapeutic advances in musculoskeletal disease · 2018Review
- Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity.Clinical rheumatology · 2017Article
- Longitudinal medical records as a complement to routine drug safety signal analysis.Pharmacoepidemiology and drug safety · 2015Article
- Rheumatic symptoms in autoimmune thyroiditis.Current rheumatology reports · 2015Review
- Assessing the prevalence of autoimmune, endocrine, gynecologic, and psychiatric comorbidities in an ethnically diverse cohort of female fibromyalgia patients: does the time from hysterectomy provide a clue?Journal of pain research · 2015Article
- Rheumatologic manifestations in Iranian patients with autoimmune thyroid diseases.Journal of clinical and diagnostic research : JCDR · 2014Article
- Fibromyalgia and chronic widespread pain in autoimmune thyroid disease.Clinical rheumatology · 2014Review
- Autoimmune thyroid disease in ankylosing spondylitis.Clinical rheumatology · 2014Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our previous study, we observed that the presence of autoimmune thyroid disease worsens fibromyalgia (FM) symptoms. The aims of this study are to evaluate whether there is a predisposition for the development of FM in patients with Hashimoto's thyroiditis (HT) with or without subclinical hypothyroidism (SCH) and in patients with SCH alone and what is the weight of antithyroid antibody positivity and SCH on FM comorbidity. Fifty-two patients, 39 affected by HT with or without SCH and 13 by SCH, were matched with 37 patients affected by FM and 25 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, antithyroperoxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and non-organ-specific autoantibodies. Clinical assessment of patients and controls included the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a visual analogue scale (VAS). Patients and controls were also characterized by the presence of diffuse pain, fatigue, paresthesiae, muscle spasms, non-restful sleep, tension headache and presence of mood disorders. FM comorbidity resulted in twelve HT subjects (31%) and none in SCH patient. In particular, FM comorbidity in HT patients without SCH was 33.3% and in HT patients with SCH was 28.5%. Based on our data, we speculate that maybe there is more than a hypothesis regarding the cause-effect relation between thyroid autoimmunity and the presence of FM, thus suggesting a hypothetical role of thyroid autoimmunity in FM pathogenesis.
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