SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011
We do not have evidence based methods for the treatment of cartilage defects in the knee.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Role of platelet-rich plasma in the treatment of osteoarthritis: a meta-analysis.The Journal of international medical research · 2020Pooled it
- Changing trends in the use of cartilage restoration techniques for the patellofemoral joint: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Pooled it
- Do cartilage lesions affect the clinical outcome of anterior cruciate ligament reconstruction? A systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Pooled it
- The comparison between the different generations of autologous chondrocyte implantation with other treatment modalities: a systematic review of clinical trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Autologous chondrocyte implantation for the treatment of chondral and osteochondral defects of the talus: a meta-analysis of available evidence.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Collagen meniscus implantation: a systematic review including rehabilitation and return to sports activity.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Clinical and Radiographic Outcomes After Treatment of Patellar Chondral Defects: A Systematic Review.Sports healthPooled it
- Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Trial
- A tri-component knee plug for the 3rd generation of autologous chondrocyte implantation.Scientific reports · 2020Article
- Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope.Stem cells international · 2020Review
- Cartilage repair surgery prevents progression of knee degeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Observational
- Pre-Clinical Translation of Second Harmonic Microscopy of Meniscal and Articular Cartilage Using a Prototype Nonlinear Microendoscope.IEEE journal of translational engineering in health and medicine · 2019Article
- Microfracture: State of the Art in Cartilage Surgery?Cartilage · 2018Review
- Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs).Genes & diseases · 2017Article
- Cartilage repair strategies in the knee: A survey of Turkish surgeons.Acta orthopaedica et traumatologica turcica · 2016Article
- BST-CarGel® Treatment Maintains Cartilage Repair Superiority over Microfracture at 5 Years in a Multicenter Randomized Controlled Trial.Cartilage · 2015Article
- Ten-year clinical and radiographic outcomes after autologous chondrocyte implantation of femoral condyles.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Article
- Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits BMP2-induced osteogenic differentiation.PloS one · 2014Article
- Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo.Arthritis research & therapy · 2013Article
- Do cartilage repair procedures prevent degenerative meniscus changes?: longitudinal t1ρ and morphological evaluation with 3.0-T MRI.The American journal of sports medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to perform a systematic review of studies concerning current treatment of chondral defects of the knee.
methodsThe relevance for evidence based data and for successful surgical treatment of cartilage defects was evaluated. From 56,098 evaluated studies, 133 studies could be further pursued. These supplied data concerning microfracturing, the osteochondral autograft transplantation system (OATS), the autologous chondrocyte implantation (ACI) and the matrix induced chondrocyte implantation (MACI). The modified Coleman Methodical Score (CMS) and the Level of Evidence (LOE) were applied to evaluate the quality.
resultsIn these studies, a total of 6,920 patients were reviewed with a median of 32 patients per study and a mean follow-up of 24 months. The mean CMS was 58 of 100 points. No study reached 100 points in the CMS. Three studies reached a level above 90. Ten studies were Level I, five studies reached Level II. Seven studies reached Level III, 111 studies Level IV. MRI scans to verify the clinical data were used by only 72 studies. The means in the modified CMS were for the different procedures as follows: ACI 58 points, MACI 57 points, microfracturing 68 points and OATS 50 points. 24 studies applied the Lysholm Score (LS) for clinical evaluation of cartilage surgery. All operative procedures yielded comparable improvements of the LS (n.s.) meaning that no operative procedure proved superior.
conclusionAs the majority of studies evaluated by this review is insufficient for EBM purposes more coherent studies with LOE of I or II are needed. Co-relating the systems of CMS and LOE and validating the applied scores seems desirable.
Indexed as
Identifiers
21085933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.