ArticlePloS one2010
Heat resistance mediated by a new plasmid encoded Clp ATPase, ClpK, as a possible novel mechanism for nosocomial persistence of Klebsiella pneumoniae.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
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- Genotypic and Phenotypic Characterization ofMicroorganisms · 2026Article
- Megaplasmids associate withbioRxiv : the preprint server for biology · 2025Article
- Molecular dynamic simulations to assess the structural variability of ClpV fromFrontiers in bioinformatics · 2025Article
- Methods for Screening and Isolating Extremely Heat-ResistantLife (Basel, Switzerland) · 2024Article
- Genetic Analyses of Rare ESBL ST628Microorganisms · 2024Article
- TheeLife · 2024Article
- Screening of Antibiotic and Virulence Genes from Whole Genome SequencedAntibiotics (Basel, Switzerland) · 2023Article
- The association between ambient temperature and antimicrobial resistance ofFrontiers in public health · 2023Article
- ESKAPE Pathogens: Looking at Clp ATPases as Potential Drug Targets.Antibiotics (Basel, Switzerland) · 2022Review
- Caseinolytic Proteins (Clp) in the GenusMolecules (Basel, Switzerland) · 2021Article
- Genomic and Phenotypic Analysis of Heat and Sanitizer Resistance in Escherichia coli from Beef in Relation to the Locus of Heat Resistance.Applied and environmental microbiology · 2021Article
- Bacterial cyclic diguanylate signaling networks sense temperature.Nature communications · 2021Article
- A recently isolated human commensal Escherichia coli ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage-derived IncY plasmid.Molecular microbiology · 2021Article
- Horizontal Transmission of Stress Resistance Genes Shape the Ecology of Beta- and Gamma-Proteobacteria.Frontiers in microbiology · 2021Review
- Resisting the Heat: Bacterial Disaggregases Rescue Cells From Devastating Protein Aggregation.Frontiers in molecular biosciences · 2021Review
- Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C.FEMS microbiology reviews · 2020Review
- Article
- Heat and Pressure Resistance inFrontiers in microbiology · 2020Article
- Protein aggregation in bacteria.FEMS microbiology reviews · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumoniae is an important opportunistic pathogen and a frequent cause of nosocomial infections. We have characterized a K. pneumoniae strain responsible for a series of critical infections in an intensive care unit over a two-year period. The strain was found to be remarkably thermotolerant providing a conceivable explanation of its persistence in the hospital environment. This marked phenotype is mediated by a novel type of Clp ATPase, designated ClpK. The clpK gene is encoded by a conjugative plasmid and we find that the clpK gene alone renders an otherwise sensitive E. coli strain resistant to lethal heat shock. Furthermore, one third of a collection of nosocomial K. pneumoniae isolates carry clpK and exhibit a heat resistant phenotype. The discovery of ClpK as a plasmid encoded factor and its profound impact on thermal stress survival sheds new light on the biological relevance of Clp ATPases in acquired environmental fitness and highlights the challenges of mobile genetic elements in fighting nosocomial infections.
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