ArticlePLoS biology2010
Genetic control of organ shape and tissue polarity.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle.Current biology : CB · 2026Article
- Shaping of developmental gradients through selection on multiple loci inScience advances · 2026Article
- Evolution of petal patterning: blooming floral diversity at the microscale.The New phytologist · 2025Review
- Evolution and development of complex floral displays.Development (Cambridge, England) · 2024Review
- Modulation of cell differentiation and growth underlies the shift from bud protection to light capture in cauline leaves.Plant physiology · 2024Article
- Developmental timing in plants.Nature communications · 2024Review
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- Using positional information to provide context for biological image analysis with MorphoGraphX 2.0.eLife · 2022Article
- Testing candidate genes linked to corolla shape variation of a pollinator shift in Rhytidophyllum (Gesneriaceae).PloS one · 2022Article
- Article
- Floral organ development goes live.Journal of experimental botany · 2020Article
- Mechanics unlocks the morphogenetic puzzle of interlocking bivalved shells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Shaping the zebrafish myotome by intertissue friction and active stress.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- An Automated Confocal Micro-Extensometer Enables in Vivo Quantification of Mechanical Properties with Cellular Resolution.The Plant cell · 2017Article
- A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics.eLife · 2017Article
- Twists and turns.eLife · 2017Article
- Growth patterns for shape-shifting elastic bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Global gene expression defines faded whorl specification of double flower domestication in Camellia.Scientific reports · 2017Article
- Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.eLife · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The mechanisms by which genes control organ shape are poorly understood. In principle, genes may control shape by modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because of interactions between patterns, orientations, and mechanical constraints during growth. Here we show how a combination of growth analysis, molecular genetics, and modelling can be used to dissect the factors contributing to shape. Using the Snapdragon (Antirrhinum) flower as an example, we show how shape development reflects local rates and orientations of tissue growth that vary spatially and temporally to form a dynamic growth field. This growth field is under the control of several dorsoventral genes that influence flower shape. The action of these genes can be modelled by assuming they modulate specified growth rates parallel or perpendicular to local orientations, established by a few key organisers of tissue polarity. Models in which dorsoventral genes only influence specified growth rates do not fully account for the observed growth fields and shapes. However, the data can be readily explained by a model in which dorsoventral genes also modify organisers of tissue polarity. In particular, genetic control of tissue polarity organisers at ventral petal junctions and distal boundaries allows both the shape and growth field of the flower to be accounted for in wild type and mutants. The results suggest that genetic control of tissue polarity organisers has played a key role in the development and evolution of shape.
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Registered trials
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