ArticlePLoS computational biology2010
Chromosome driven spatial patterning of proteins in bacteria.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Helicity of a confined bottlebrush ring polymer.Macromolecules · 2026Article
- Review
- A Hi-C data-integrated model elucidates E. coli chromosome's multiscale organization at various replication stages.Nucleic acids research · 2021Article
- Article
- Crosstalk Regulation Between Bacterial Chromosome Replication and Chromosome Partitioning.Frontiers in microbiology · 2019Review
- Review
- DNA Internal Motion Likely Accelerates Protein Target Search in a Packed Nucleoid.Biophysical journal · 2017Article
- Operational Principles for the Dynamics of the In Vitro ParA-ParB System.PLoS computational biology · 2015Article
- Effects of molecular noise on bistable protein distributions in rod-shaped bacteria.Interface focus · 2014Article
- Cytoplasmic dynamics reveals two modes of nucleoid-dependent mobility.Biophysical journal · 2014Article
- Localization of aggregating proteins in bacteria depends on the rate of addition.Frontiers in microbiology · 2014Article
- How do bacteria localize proteins to the cell pole?Journal of cell science · 2014Review
- Oligomerization and higher-order assembly contribute to sub-cellular localization of a bacterial scaffold.Molecular microbiology · 2013Article
- Article
- Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization.The Journal of cell biology · 2013Article
- Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect.PLoS computational biology · 2013Article
- Article
- Gene location and DNA density determine transcription factor distributions in Escherichia coli.Molecular systems biology · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spatial patterning of proteins in bacteria plays an important role in many processes, from cell division to chemotaxis. In the asymmetrically dividing bacteria Caulobacter crescentus, a scaffolding protein, PopZ, localizes to both poles and aids the differential patterning of proteins between mother and daughter cells during division. Polar patterning of misfolded proteins in Escherichia coli has also been shown, and likely plays an important role in cellular ageing. Recent experiments on both of the above systems suggest that the presence of chromosome free regions along with protein multimerization may be a mechanism for driving the polar localization of proteins. We have developed a simple physical model for protein localization using only these two driving mechanisms. Our model reproduces all the observed patterns of PopZ and misfolded protein localization--from diffuse, unipolar, and bipolar patterns and can also account for the observed patterns in a variety of mutants. The model also suggests new experiments to further test the role of the chromosome in driving protein patterning, and whether such a mechanism is responsible for helping to drive the differentiation of the cell poles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.