ArticlePLoS genetics2010
A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the sodium transporter AtHKT1;1.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 1 of them a synthesis that pooled it.
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163 citing papers in PubMed, 1 synthesis or guideline pooled it, 359 citations in OpenAlex.
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- Comparison of linkage and association mapping in MAGIC lines identifies AtMTP3 as a new gene controlling natural variation in leaf zinc concentration in Arabidopsis.Journal of experimental botany · 2025Article
- Contribution of Range-Wide and Short-Scale Chemical Soil Variation to Local Adaptation in a Tropical Montane Forest Tree.Evolutionary applications · 2025Article
- Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis.PLoS genetics · 2025Article
- Multiple independent MGR5 alleles contribute to a clinal pattern in leaf magnesium across the distribution of Arabidopsis thaliana.The New phytologist · 2025Article
- A SnRK2-HAK regulatory module confers natural variation of salt tolerance in maize.Nature communications · 2025Article
- Environmental genome-wide association studies across precipitation regimes reveal that the E3 ubiquitin ligase MBR1 regulates plant adaptation to rainy environments.Plant communications · 2024Article
- Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification.Nature communications · 2024Article
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- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- Elemental profiling and genome-wide association studies reveal genomic variants modulating ionomic composition inFrontiers in plant science · 2024Article
- Chasing the mechanisms of ecologically adaptive salinity tolerance.Plant communications · 2023Review
- Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana.The Plant cell · 2023Article
- Genome-wide association study reveals WRKY42 as a novel plant transcription factor that influences oviposition preference of Pieris butterflies.Journal of experimental botany · 2023Article
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103 more citing papers are in PubMed but not listed here.
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12 authors at 4 institutions in 2 countries.
Funding
Abstract
The genetic model plant Arabidopsis thaliana, like many plant species, experiences a range of edaphic conditions across its natural habitat. Such heterogeneity may drive local adaptation, though the molecular genetic basis remains elusive. Here, we describe a study in which we used genome-wide association mapping, genetic complementation, and gene expression studies to identify cis-regulatory expression level polymorphisms at the AtHKT1;1 locus, encoding a known sodium (Na(+)) transporter, as being a major factor controlling natural variation in leaf Na(+) accumulation capacity across the global A. thaliana population. A weak allele of AtHKT1;1 that drives elevated leaf Na(+) in this population has been previously linked to elevated salinity tolerance. Inspection of the geographical distribution of this allele revealed its significant enrichment in populations associated with the coast and saline soils in Europe. The fixation of this weak AtHKT1;1 allele in these populations is genetic evidence supporting local adaptation to these potentially saline impacted environments.
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