ArticlePloS one2010
Serum neurotrophin profile in systemic sclerosis.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Prevalence and Clinical Associations of Antiphospholipid Antibodies in Systemic Sclerosis: New Data From a French Cross-Sectional Study, Systematic Review, and Meta-Analysis.Frontiers in immunology · 2018Pooled it
- Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension.Arthritis research & therapy · 2022Article
- Serum BDNF and cognitive dysfunction in SLE: findings from a cohort of 111 patients.Clinical rheumatology · 2022Article
- Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review).Experimental and therapeutic medicine · 2021Review
- Seasonal Expression of NGF and Its Cognate Receptors in the Ovaries of Grey Squirrels (Animals : an open access journal from MDPI · 2020Article
- Changes in serum NGF levels after the exercise load in dogs: a pilot study.The Journal of veterinary medical science · 2016Article
- Raynaud's phenomenon: new aspects of pathogenesis and the role of nailfold videocapillaroscopy.Reumatologia · 2015Review
- Serum nerve grow factor and brain-derived neurotrophic factor profiles in Sjögren's syndrome concomitant with interstitial lung disease.Clinical rheumatology · 2014Article
- Serum and lymphocytic neurotrophins profiles in systemic lupus erythematosus: a case-control study.PloS one · 2013Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurotrophins (NTs) are able to activate lymphocytes and fibroblasts; they can modulate angiogenesis and sympathic vascular function. Thus, they can be implicated in the three pathogenic processes of systemic sclerosis (SSc). The aims of this study are to determine blood levels of Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) in SSc and to correlate them with clinical and biological data.
methodsSerum samples were obtained from 55 SSc patients and 32 control subjects to measure NTs levels by ELISA and to determine their relationships with SSc profiles.
findingsSerum NGF levels were higher in SSc patients (288.26 ± 170.34 pg/mL) than in control subjects (170.34 ± 50.8 pg/mL, p<0.001) and correlated with gammaglobulins levels and the presence of both anti-cardiolipin and anti-Scl-70 antibodies (p<0.05). In contrast, BDNF levels were lower in SSc patients than in controls (1121.9 ± 158.1 vs 1372.9 ± 190.9 pg/mL, p<0.0001), especially in pulmonary arterial hypertension and diffuse SSc as compared to limited forms (all p<0.05). NT-3 levels were similar in SSc and in the control group (2657.2 ± 2296 vs 2959.3 ± 2555 pg/mL, NS). BDNF levels correlated negatively with increased NGF levels in the SSc group (and not in controls).
conclusionLow BDNF serum levels were not previously documented in SSc, particularly in the diffuse SSc subset and in patients with pulmonary hypertension or anti-Scl-70 antibodies. The negative correlation between NGF and BDNF levels observed in SSc and not in healthy controls could be implicated in sympathic vascular dysfunction in SSc.
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