ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology.Journal of molecular and cellular cardiology plus · 2023Article
- OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiology.bioRxiv : the preprint server for biology · 2023Article
- Simultaneous Widefield Voltage and Dye-Free Optical Mapping Quantifies Electromechanical Waves in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.ACS photonics · 2023Article
- Recent Advances in Designing Electroconductive Biomaterials for Cardiac Tissue Engineering.Advanced healthcare materials · 2022Review
- Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies.BioMed research international · 2021Review
- Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Recapitulation of microtissue models connected with real-time readout systems via 3D printing technology.Journal of thoracic disease · 2017Article
- OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology.Nature communications · 2016Article
- Emergent Global Contractile Force in Cardiac Tissues.Biophysical journal · 2016Article
- Cardiac Optogenetics: Enhancement by All-trans-Retinal.Scientific reports · 2015Article
- Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces.Nature methods · 2015Article
- Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span.The Journal of clinical investigation · 2013Article
- Article
- Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes.Stem cell reports · 2013Article
- Self-organization and the self-assembling process in tissue engineering.Annual review of biomedical engineering · 2013Review
- Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.Biomaterials · 2012Article
- Cardiac cellular coupling and the spread of early instabilities in intracellular Ca2+.Biophysical journal · 2012Article
- Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip.Lab on a chip · 2011Article
- Engineered cardiac tissues.Current opinion in biotechnology · 2011Review
- Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.Pflugers Archiv : European journal of physiology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In vitro models of cardiac hypertrophy focus exclusively on applying "external" dynamic signals (electrical, mechanical, and chemical) to achieve a hypertrophic state. In contrast, here we set out to demonstrate the role of "self-organized" cellular architecture and activity in reprogramming cardiac cell/tissue function toward a hypertrophic phenotype. We report that in neonatal rat cardiomyocyte culture, subtle out-of-plane microtopographic cues alter cell attachment, increase biomechanical stresses, and induce not only structural remodeling, but also yield essential molecular and electrophysiological signatures of hypertrophy. Increased cell size and cell binucleation, molecular up-regulation of released atrial natriuretic peptide, altered expression of classic hypertrophy markers, ion channel remodeling, and corresponding changes in electrophysiological function indicate a state of hypertrophy on par with other in vitro and in vivo models. Clinically used antihypertrophic pharmacological treatments partially reversed hypertrophic behavior in this in vitro model. Partial least-squares regression analysis, combining gene expression and functional data, yielded clear separation of phenotypes (control: cells grown on flat surfaces; hypertrophic: cells grown on quasi-3-dimensional surfaces and treated). In summary, structural surface features can guide cardiac cell attachment, and the subsequent syncytial behavior can facilitate trophic signals, unexpectedly on par with externally applied mechanical, electrical, and chemical stimulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.