ArticleJournal of neurophysiology2011
Graded reductions in oxygenation evoke graded reconfiguration of the isolated respiratory network.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- The psychophysiology of the sigh: I: The sigh from the physiological perspective.Biological psychology · 2022Review
- The sigh and related behaviors.Handbook of clinical neurology · 2022Review
- Role of deep breaths in ultrasonic vocal production of Sprague-Dawley rats.Journal of neurophysiology · 2020Article
- Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development.Respiratory physiology & neurobiology · 2019Review
- Isolated adult turtle brainstems exhibit central hypoxic chemosensitivity.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2018Article
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity.Nature communications · 2018Article
- Transcriptome of neonatal preBötzinger complex neurones in Dbx1 reporter mice.Scientific reports · 2017Article
- Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex.Frontiers in physiology · 2017Article
- The emerging role of AMPK in the regulation of breathing and oxygen supply.The Biochemical journal · 2016Review
- Article
- Progressive Changes in a Distributed Neural Circuit Underlie Breathing Abnormalities in Mice Lacking MeCP2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex.Frontiers in neuroscience · 2016Article
- Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism.Respiratory physiology & neurobiology · 2015Article
- Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice.The Journal of physiology · 2015Article
- When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Change in network connectivity during fictive-gasping generation in hypoxia: prevention by a metabolic intermediate.Frontiers in physiology · 2014Article
- The integrative role of the sigh in psychology, physiology, pathology, and neurobiology.Progress in brain research · 2014Review
- Central and peripheral factors contributing to obstructive sleep apneas.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Neurons depend on aerobic metabolism, yet are very sensitive to oxidative stress and, as a consequence, typically operate in a low O(2) environment. The balance between blood flow and metabolic activity, both of which can vary spatially and dynamically, suggests that local O(2) availability markedly influences network output. Yet the understanding of the underlying O(2)-sensing mechanisms is limited. Are network responses regulated by discrete O(2)-sensing mechanisms or, rather, are they the consequence of inherent O(2) sensitivities of mechanisms that generate the network activity? We hypothesized that a broad range of O(2) tensions progressively modulates network activity of the pre-Bötzinger complex (preBötC), a neuronal network critical to the central control of breathing. Rhythmogenesis was measured from the preBötC in transverse neonatal mouse brain stem slices that were exposed to graded reductions in O(2) between 0 and 95% O(2), producing tissue oxygenation values ranging from 20 ± 18 (mean ± SE) to 440 ± 56 Torr at the slice surface, respectively. The response of the preBötC to graded changes in O(2) is progressive for some metrics and abrupt for others, suggesting that different aspects of the respiratory network have different sensitivities to O(2).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.