ArticleJournal of virology2011
Minor oral lesions facilitate transmission of chronic wasting disease.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- The Evolution of Experimental Rodent Models for Prion Diseases.Journal of neurochemistry · 2025Review
- Identification of chronic wasting disease prions in decaying tongue tissues from exhumed white-tailed deer.mSphere · 2023Article
- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Review
- Article
- Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice.The Journal of veterinary medical science · 2021Article
- Oral Ingestion of Synthetically Generated Recombinant Prion Is Sufficient to Cause Prion Disease in Wild-Type Mice.Pathogens (Basel, Switzerland) · 2020Article
- Very low oral exposure to prions of brain or saliva origin can transmit chronic wasting disease.PloS one · 2020Article
- Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids.Scientific reports · 2019Article
- Effect of co-infection with a small intestine-restricted helminth pathogen on oral prion disease pathogenesis in mice.Scientific reports · 2019Article
- Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling.Journal of clinical microbiology · 2018Article
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- Pathways of Prion Spread during Early Chronic Wasting Disease in Deer.Journal of virology · 2017Article
- Prions efficiently cross the intestinal barrier after oral administration: Study of the bioavailability, and cellular and tissue distribution in vivo.Scientific reports · 2016Article
- Detection and Quantification of CWD Prions in Fixed Paraffin Embedded Tissues by Real-Time Quaking-Induced Conversion.Scientific reports · 2016Article
- The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis.Journal of virology · 2015Article
- Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease.Vaccine · 2015Article
- Lesion of the olfactory epithelium accelerates prion neuroinvasion and disease onset when prion replication is restricted to neurons.PloS one · 2015Article
- Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion.The Journal of general virology · 2015Article
- Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy.Journal of virology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
While chronic wasting disease (CWD) prion transmission, entry, and trafficking remain incompletely elucidated, natural exposure of the oral and/or nasal mucous membranes seems certain. Cervids commonly sustain minor lesions on oral mucous membranes that could have an impact on susceptibility to prion infection. To explore this potential cofactor, we studied cohorts of cervid PrP transgenic mice with or without superficial abrasions on the lingual mucosa to determine whether minor oral mucosa lesions may enhance susceptibility to CWD infections. Results demonstrated that minor lingual abrasions substantially facilitate CWD transmission, revealing a cofactor that may be significant in cervids and perhaps other species.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.