ArticleJournal of virology2011
Identification of novel endogenous betaretroviruses which are transcribed in the bovine placenta.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Epithelial-Mesenchymal Transitions Leading to Conceptus Adhesion in Ruminants: Early Pregnancy Events in Cattle.International journal of molecular sciences · 2025Review
- Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle.Biomolecules · 2023Review
- Review
- Viral-derived DNA invasion and individual variation in an Indonesian population of large flying fox Pteropus vampyrus.The Journal of veterinary medical science · 2021Article
- Differential Expression Pattern of Retroviral Envelope Gene in the Equine Placenta.Frontiers in veterinary science · 2021Article
- Novel endogenous retrovirus-derived transcript expressed in the bovine placenta is regulated by WNT signaling.The Biochemical journal · 2017Article
- Identification of novel simian endogenous retroviruses that are indistinguishable from simian retrovirus (SRV) on current SRV diagnostic assays.Journal of medical primatology · 2017Article
- High Expression of Endogenous Retroviral Envelope Gene in the Equine Fetal Part of the Placenta.PloS one · 2016Article
- Conceptus implantation and placentation: molecules related to epithelial-mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes.Reproductive medicine and biology · 2016Review
- Recent advances in the study of active endogenous retrovirus envelope glycoproteins in the mammalian placenta.Virologica Sinica · 2015Review
- Review
- Endogenous retroviruses in domestic animals.Current genomics · 2014Article
- Dysfunction of bovine endogenous retrovirus K2 envelope glycoprotein is related to unsuccessful intracellular trafficking.Journal of virology · 2014Article
- Fematrin-1 is involved in fetomaternal cell-to-cell fusion in Bovinae placenta and has contributed to diversity of ruminant placentation.Journal of virology · 2013Article
- Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentation.Genome biology and evolution · 2013Article
- Application of next generation sequencing in mammalian embryogenomics: lessons learned from endogenous betaretroviruses of sheep.Animal reproduction science · 2012Review
- Bovine trophoblastic cell differentiation and binucleation involves enhanced endogenous retrovirus element expression.Reproductive biology and endocrinology : RB&E · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequences of retroviral origin occupy approximately 10% of mammalian genomes. Various infectious endogenous retroviruses (ERVs) and functional retroviral elements have been reported for several mammals but not cattle. Here, we identified two proviruses, designated bovine endogenous retrovirus K1 (BERV-K1) and BERV-K2, containing full-length envelope (env) genes in the bovine genome. Phylogenetic analysis revealed that they belong to the genus Betaretrovirus. By reverse transcription (RT)-PCR, both BERV-K1 and -K2 env mRNAs were detected in the placenta and cultured bovine trophoblast cells. Real-time RT-PCR analysis using RNAs isolated from various bovine tissues revealed that BERV-K1 env mRNA was preferentially expressed in the placenta. Moreover, we also found the expression of doubly spliced transcripts, named the REBK1 and REBK2 genes. Both the REBK1 and REBK2 proteins have motifs for a putative nuclear localization signal and a nuclear export signal. REBK1 and REBK2 fused with green fluorescent proteins were localized mainly in the nuclei when they were expressed in bovine and porcine cells. In the env and 3' long terminal repeats of BERV-K1 and -K2, we found regulatory elements responsible for the splicing and transport of viral RNAs and/or translation of the env genes. Although we have not identified the expressed Env proteins in bovine tissues, these data suggest that both BERV-K1 and BERV-K2 express Env proteins and that these proteins may have physiological functions in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.