ArticleJournal of the Royal Society, Interface2011
The importance of structured noise in the generation of self-organizing tissue patterns through contact-mediated cell-cell signalling.
Article in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
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- Forced into shape: Mechanical forces in Drosophila development and homeostasis.Seminars in cell & developmental biology · 2021Review
- A role for actomyosin contractility in Notch signaling.BMC biology · 2019Article
- A spatial frequency spectral peakedness model predicts discrimination performance of regularity in dot patterns.Vision research · 2018Article
- Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.Developmental cell · 2017Article
- Comparing individual-based approaches to modelling the self-organization of multicellular tissues.PLoS computational biology · 2017Article
- A new mechanism for spatial pattern formation via lateral and protrusion-mediated lateral signalling.Journal of the Royal Society, Interface · 2016Article
- Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.Development (Cambridge, England) · 2016Article
- Emergent patterns from probabilistic generalizations of lateral activation and inhibition.Journal of the Royal Society, Interface · 2016Article
- Pattern selection by dynamical biochemical signals.Biophysical journal · 2015Article
- Tunable diffusive lateral inhibition in chemical cells.The European physical journal. E, Soft matter · 2015Article
- An absolute interval scale of order for point patterns.Journal of the Royal Society, Interface · 2014Article
- Article
- Morphogen transport.Development (Cambridge, England) · 2013Article
- On the role of lateral stabilization during early patterning in the pancreas.Journal of the Royal Society, Interface · 2013Article
- β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.Molecular biology of the cell · 2011Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Lateral inhibition provides the basis for a self-organizing patterning system in which distinct cell states emerge from an otherwise uniform field of cells. The development of the microchaete bristle pattern on the notum of the fruitfly, Drosophila melanogaster, has long served as a popular model of this process. We recently showed that this bristle pattern depends upon a population of dynamic, basal actin-based filopodia, which span multiple cell diameters. These protrusions establish transient signalling contacts between non-neighbouring cells, generating a type of structured noise that helps to yield a well-ordered and spaced pattern of bristles. Here, we develop a general model of protrusion-based patterning to analyse the role of noise in this process. Using a simple asynchronous cellular automata rule-based model we show that this type of structured noise drives the gradual refinement of lateral inhibition-mediated patterning, as the system moves towards a stable configuration in which cells expressing the inhibitory signal are near-optimally packed. By analysing the effects of introducing thresholds required for signal detection in this model of lateral inhibition, our study shows how filopodia-mediated cell-cell communication can generate complex patterns of spots and stripes, which, in the presence of signalling noise, align themselves across a patterning field. Thus, intermittent protrusion-based signalling has the potential to yield robust self-organizing tissue-wide patterns without the need to invoke diffusion-mediated signalling.
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