ArticleBMC cell biology2010
Robust patterns in the stochastic organization of filopodia.
Article in BMC cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Stromule Geometry Allows Optimal Spatial Regulation of Organelle Interactions in the Quasi-2D Cytoplasm.Plant & cell physiology · 2024Article
- Hs27 fibroblast response to contact guidance cues.Scientific reports · 2023Article
- Article
- The Process of Filopodia Induction during HPV Infection.Viruses · 2022Article
- Following the footprints of variability during filopodial growth.European biophysics journal : EBJ · 2020Article
- Quantifying Filopodia in Cultured Astrocytes by an Algorithm.Neurochemical research · 2017Article
- Filopodia formation and endosome clustering induced by mutant plus-end-directed myosin VI.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration.British journal of pharmacology · 2015Article
- Topographic cell instructive patterns to control cell adhesion, polarization and migration.Journal of the Royal Society, Interface · 2014Article
- FiloDetect: automatic detection of filopodia from fluorescence microscopy images.BMC systems biology · 2013Article
- Assembling neurospheres: dynamics of neural progenitor/stem cell aggregation probed using an optical trap.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFilopodia are actin-based cellular projections that have a critical role in initiating and sustaining directional migration in vertebrate cells. Filopodia are highly dynamic structures that show a rich diversity in appearance and behavior. While there are several mathematical models of filopodia initiation and growth, testing the capacity of these theoretical models in predicting empirical behavior has been hampered by a surprising shortage of quantitative data related to filopodia. Neither is it clear how quantitatively robust the cellular filopodial network is and how perturbations alter it.
resultsWe have measured the length and interfilopodial separation distances of several thousand filopodia in the rodent cell line Rat2 and measured these parameters in response to genetic, chemical and physical perturbation. Our work shows that length and separation distance have a lognormal pattern distribution over their entire detection range (0.4 μm to 50 μm).
conclusionsWe find that the lognormal distribution of length and separation is robust and highly resistant to perturbation. We also find that length and separation are independent variables. Most importantly, our empirical data is not entirely in agreement with predictions made based on existing theoretical models and that filopodial size and separation are an order of magnitude larger than what existing models suggest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.